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- W2122091356 endingPage "1242" @default.
- W2122091356 startingPage "1233" @default.
- W2122091356 abstract "Polyketides are important bioactive natural products biosynthesized by bacteria, fungi, and plants. The enzymes that synthesize polyketides are collectively referred to as polyketide synthases (PKSs). Because many of the natural hosts that produce polyketides are difficult to culture or manipulate, establishing a universal heterologous host that is genetically tractable has become an important goal toward the engineered biosynthesis of polyketides and analogues. Here, we summarize the recent progresses in engineering Escherichia coli as a heterologous host for reconstituting PKSs of different types. Our increased understanding of PKS enzymology and structural biology, combined with new tools in protein engineering, metabolic engineering, and synthetic biology, has firmly established E. coli as a powerful host for producing polyketides." @default.
- W2122091356 created "2016-06-24" @default.
- W2122091356 creator A5015794568 @default.
- W2122091356 creator A5049078993 @default.
- W2122091356 creator A5086448413 @default.
- W2122091356 date "2010-09-19" @default.
- W2122091356 modified "2023-10-03" @default.
- W2122091356 title "Engineered polyketide biosynthesis and biocatalysis in Escherichia coli" @default.
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- W2122091356 doi "https://doi.org/10.1007/s00253-010-2860-4" @default.
- W2122091356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2981745" @default.
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- W2122091356 hasPublicationYear "2010" @default.
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