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- W2122092305 endingPage "20130514" @default.
- W2122092305 startingPage "20130514" @default.
- W2122092305 abstract "The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wide scale is broadly associated with active gene expression, with its mono-, di- and trimethylated forms differentially enriched at promoter and enhancer and other regulatory sequences. In addition to these rare genetic syndromes, dysregulated H3K4 methylation could also play a role in the pathophysiology of some cases diagnosed with autism or schizophrenia, two conditions which on a genome-wide scale are associated with H3K4 methylation changes at hundreds of loci in a subject-specific manner. Importantly, the reported alterations for some of the diseased brain specimens included a widespread broadening of H3K4 methylation profiles at gene promoters, a process that could be regulated by the UpSET(KMT2E/MLL5)-histone deacetylase complex. Furthermore, preclinical studies identified maternal immune activation, parental care and monoaminergic drugs as environmental determinants for brain-specific H3K4 methylation. These novel insights into the epigenetic risk architectures of neurodevelopmental disease will be highly relevant for efforts aimed at improved prevention and treatment of autism and psychosis spectrum disorders." @default.
- W2122092305 created "2016-06-24" @default.
- W2122092305 creator A5025600687 @default.
- W2122092305 creator A5062832120 @default.
- W2122092305 creator A5084369008 @default.
- W2122092305 creator A5090255481 @default.
- W2122092305 date "2014-09-26" @default.
- W2122092305 modified "2023-10-12" @default.
- W2122092305 title "Regulation of histone H3K4 methylation in brain development and disease" @default.
- W2122092305 cites W1481706430 @default.
- W2122092305 cites W1528147088 @default.
- W2122092305 cites W1964444099 @default.
- W2122092305 cites W1971716475 @default.
- W2122092305 cites W1977019957 @default.
- W2122092305 cites W1981030303 @default.
- W2122092305 cites W1981354816 @default.
- W2122092305 cites W1985274787 @default.
- W2122092305 cites W1985543209 @default.
- W2122092305 cites W1986396604 @default.
- W2122092305 cites W1987097017 @default.
- W2122092305 cites W1987695396 @default.
- W2122092305 cites W1990980202 @default.
- W2122092305 cites W1992213480 @default.
- W2122092305 cites W1993341911 @default.
- W2122092305 cites W1994872818 @default.
- W2122092305 cites W1996358062 @default.
- W2122092305 cites W1998195802 @default.
- W2122092305 cites W2001555806 @default.
- W2122092305 cites W2002676132 @default.
- W2122092305 cites W2010780719 @default.
- W2122092305 cites W2010915225 @default.
- W2122092305 cites W2012089320 @default.
- W2122092305 cites W2013928795 @default.
- W2122092305 cites W2015416439 @default.
- W2122092305 cites W2016024994 @default.
- W2122092305 cites W2017398815 @default.
- W2122092305 cites W2020034827 @default.
- W2122092305 cites W2020958679 @default.
- W2122092305 cites W2022310838 @default.
- W2122092305 cites W2022414857 @default.
- W2122092305 cites W2024584416 @default.
- W2122092305 cites W2024663595 @default.
- W2122092305 cites W2025570007 @default.
- W2122092305 cites W2027521783 @default.
- W2122092305 cites W2028449397 @default.
- W2122092305 cites W2028679671 @default.
- W2122092305 cites W2035457626 @default.
- W2122092305 cites W2036158314 @default.
- W2122092305 cites W2037112086 @default.
- W2122092305 cites W2038604383 @default.
- W2122092305 cites W2040408325 @default.
- W2122092305 cites W2040675004 @default.
- W2122092305 cites W2040801017 @default.
- W2122092305 cites W2043534093 @default.
- W2122092305 cites W2044757832 @default.
- W2122092305 cites W2047498240 @default.
- W2122092305 cites W2047573503 @default.
- W2122092305 cites W2053901332 @default.
- W2122092305 cites W2053964757 @default.
- W2122092305 cites W2054564838 @default.
- W2122092305 cites W2054621094 @default.
- W2122092305 cites W2055287480 @default.
- W2122092305 cites W2055421069 @default.
- W2122092305 cites W2060429763 @default.
- W2122092305 cites W2063563320 @default.
- W2122092305 cites W2064474429 @default.
- W2122092305 cites W2064959296 @default.
- W2122092305 cites W2067523496 @default.
- W2122092305 cites W2068194528 @default.
- W2122092305 cites W2069351794 @default.
- W2122092305 cites W2075244861 @default.
- W2122092305 cites W2075897158 @default.
- W2122092305 cites W2079253965 @default.
- W2122092305 cites W2080657904 @default.
- W2122092305 cites W2081302124 @default.
- W2122092305 cites W2081362935 @default.
- W2122092305 cites W2081472664 @default.
- W2122092305 cites W2084885369 @default.
- W2122092305 cites W2086039500 @default.
- W2122092305 cites W2092027270 @default.
- W2122092305 cites W2096083625 @default.
- W2122092305 cites W2100663971 @default.
- W2122092305 cites W2105767248 @default.
- W2122092305 cites W2111390374 @default.
- W2122092305 cites W2115862579 @default.
- W2122092305 cites W2116414062 @default.
- W2122092305 cites W2119799034 @default.
- W2122092305 cites W2121910267 @default.
- W2122092305 cites W2124418801 @default.
- W2122092305 cites W2124607109 @default.
- W2122092305 cites W2126917138 @default.
- W2122092305 cites W2133938268 @default.
- W2122092305 cites W2134052811 @default.
- W2122092305 cites W2134300330 @default.
- W2122092305 cites W2137271973 @default.
- W2122092305 cites W2137852781 @default.
- W2122092305 cites W2138196920 @default.
- W2122092305 cites W2138976678 @default.