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- W2122100041 abstract "Phenotypic heterogeneity within tumors has been noted by pathologists for a long time. Such heterogeneity may have several causes, ranging from dynamic cellular biological responses to, for example, changes in the microenvironment, varying differentiation levels of cells within a given tumor, or inherent changes in genetic information in the form of either epigenetic changes or more stable genomic/ genetic changes. Evaluation of such mixed phenotypes has been problematic from both prognostic and treatment perspectives. The existence of clonal karyotypic heterogeneity has been documented for several tumor types, and cytogenetic investigations have revealed coexisting related but divergent subclones in several tumor types. In addition, comparative genome hybridization analyses have indicated an underlying heterogeneity with respect to copy number alterations and to the presence of subclones with different sets of genomic alterations [1]. Furthermore, investigations based on the sequencing of more than one gene in the same biopsy revealed that some mutations are present in" @default.
- W2122100041 created "2016-06-24" @default.
- W2122100041 creator A5031028431 @default.
- W2122100041 date "2015-04-01" @default.
- W2122100041 modified "2023-09-23" @default.
- W2122100041 title "Heterogeneous Challenges for Urologic Cancers" @default.
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- W2122100041 doi "https://doi.org/10.1016/j.eururo.2014.10.042" @default.
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