FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122109972> ?p ?o ?g. }

• W2122109972 endingPage "334" @default.
• W2122109972 startingPage "323" @default.
• W2122109972 abstract "We reinvestigated the synthesis of [N-methyl-(11)C]vorozole, a radiotracer for aromatase, and discovered the presence of an N-methyl isomer which was not removed in the original purification method. Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole.Norvorozole was alkylated with [(11)C]methyl iodide as previously described and also with unlabeled methyl iodide. A high-performance liquid chromatography (HPLC) method was developed to separate the regioisomers. Nuclear magnetic resonance (NMR) spectroscopy ((13)C and 2D-nuclear Overhauser effect spectroscopy NMR) was used to identify and assign structures to the N-methylated products. Pure [N-methyl-(11)C]vorozole and the contaminating isomer were compared by PET imaging in the baboon.Methylation of norvorozole resulted in a mixture of isomers (1:1:1 ratio) based on new HPLC analysis using a pentafluorophenylpropyl bonded silica column, in which vorozole coeluted one of its isomers under the original HPLC conditions. Baseline separation of the three labeled isomers was achieved. The N-3 isomer was the contaminant of vorozole, thus correcting the original assignment of isomers. PET studies of pure [N-methyl-(11)C]vorozole with and without the contaminating N-3 isomer revealed that only [N-methyl-(11)C]vorozole binds to aromatase. [N-methyl-(11)C]Vorozole accumulated in all brain regions with highest accumulation in the aromatase-rich amygdala and preoptic area. Accumulation was blocked with vorozole and letrozole consistent with reports of some level of aromatase in many brain regions.The discovery of a contaminating labeled isomer and the development of a method for isolating pure [N-methyl-(11)C]vorozole combine to provide a new scientific tool for PET studies of the biology of aromatase and for drug research and development." @default.
• W2122109972 created "2016-06-24" @default.
• W2122109972 creator A5002434403 @default.
• W2122109972 creator A5013073021 @default.
• W2122109972 creator A5019780098 @default.
• W2122109972 creator A5022467774 @default.
• W2122109972 creator A5026299628 @default.
• W2122109972 creator A5035300611 @default.
• W2122109972 creator A5038672981 @default.
• W2122109972 creator A5041862198 @default.
• W2122109972 creator A5043538440 @default.
• W2122109972 creator A5048198167 @default.
• W2122109972 creator A5062638994 @default.
• W2122109972 creator A5076076475 @default.
• W2122109972 date "2009-04-01" @default.
• W2122109972 modified "2023-09-25" @default.
• W2122109972 title "Reinvestigation of the synthesis and evaluation of [N-methyl-11C]vorozole, a radiotracer targeting cytochrome P450 aromatase" @default.
• W2122109972 cites W1592199148 @default.
• W2122109972 cites W1963951882 @default.
• W2122109972 cites W1964552630 @default.
• W2122109972 cites W1982555862 @default.
• W2122109972 cites W1984317807 @default.
• W2122109972 cites W1988711081 @default.
• W2122109972 cites W1995012620 @default.
• W2122109972 cites W2003207008 @default.
• W2122109972 cites W2003437529 @default.
• W2122109972 cites W2011978713 @default.
• W2122109972 cites W2012060632 @default.
• W2122109972 cites W2020229546 @default.
• W2122109972 cites W2022743236 @default.
• W2122109972 cites W2026602426 @default.
• W2122109972 cites W2034323087 @default.
• W2122109972 cites W2042302140 @default.
• W2122109972 cites W2043830388 @default.
• W2122109972 cites W2049432588 @default.
• W2122109972 cites W2058509005 @default.
• W2122109972 cites W2058741810 @default.
• W2122109972 cites W2077613782 @default.
• W2122109972 cites W2082406831 @default.
• W2122109972 cites W2083615536 @default.
• W2122109972 cites W2136406425 @default.
• W2122109972 cites W2147821265 @default.
• W2122109972 cites W2168514023 @default.
• W2122109972 doi "https://doi.org/10.1016/j.nucmedbio.2008.12.013" @default.
• W2122109972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3693459" @default.
• W2122109972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19324278" @default.
• W2122109972 hasPublicationYear "2009" @default.
• W2122109972 type Work @default.
• W2122109972 sameAs 2122109972 @default.
• W2122109972 citedByCount "25" @default.
• W2122109972 countsByYear W21221099722012 @default.
• W2122109972 countsByYear W21221099722013 @default.
• W2122109972 countsByYear W21221099722014 @default.
• W2122109972 countsByYear W21221099722015 @default.
• W2122109972 countsByYear W21221099722016 @default.
• W2122109972 countsByYear W21221099722019 @default.
• W2122109972 countsByYear W21221099722020 @default.
• W2122109972 countsByYear W21221099722022 @default.
• W2122109972 countsByYear W21221099722023 @default.
• W2122109972 crossrefType "journal-article" @default.
• W2122109972 hasAuthorship W2122109972A5002434403 @default.
• W2122109972 hasAuthorship W2122109972A5013073021 @default.
• W2122109972 hasAuthorship W2122109972A5019780098 @default.
• W2122109972 hasAuthorship W2122109972A5022467774 @default.
• W2122109972 hasAuthorship W2122109972A5026299628 @default.
• W2122109972 hasAuthorship W2122109972A5035300611 @default.
• W2122109972 hasAuthorship W2122109972A5038672981 @default.
• W2122109972 hasAuthorship W2122109972A5041862198 @default.
• W2122109972 hasAuthorship W2122109972A5043538440 @default.
• W2122109972 hasAuthorship W2122109972A5048198167 @default.
• W2122109972 hasAuthorship W2122109972A5062638994 @default.
• W2122109972 hasAuthorship W2122109972A5076076475 @default.
• W2122109972 hasBestOaLocation W21221099722 @default.
• W2122109972 hasConcept C121608353 @default.
• W2122109972 hasConcept C155647269 @default.
• W2122109972 hasConcept C179998833 @default.
• W2122109972 hasConcept C185592680 @default.
• W2122109972 hasConcept C202235601 @default.
• W2122109972 hasConcept C2776166826 @default.
• W2122109972 hasConcept C2778504769 @default.
• W2122109972 hasConcept C2780073701 @default.
• W2122109972 hasConcept C43617362 @default.
• W2122109972 hasConcept C530470458 @default.
• W2122109972 hasConcept C54355233 @default.
• W2122109972 hasConcept C66974803 @default.
• W2122109972 hasConcept C71240020 @default.
• W2122109972 hasConcept C86803240 @default.
• W2122109972 hasConceptScore W2122109972C121608353 @default.
• W2122109972 hasConceptScore W2122109972C155647269 @default.
• W2122109972 hasConceptScore W2122109972C179998833 @default.
• W2122109972 hasConceptScore W2122109972C185592680 @default.
• W2122109972 hasConceptScore W2122109972C202235601 @default.
• W2122109972 hasConceptScore W2122109972C2776166826 @default.
• W2122109972 hasConceptScore W2122109972C2778504769 @default.
• W2122109972 hasConceptScore W2122109972C2780073701 @default.
• W2122109972 hasConceptScore W2122109972C43617362 @default.
• W2122109972 hasConceptScore W2122109972C530470458 @default.
• W2122109972 hasConceptScore W2122109972C54355233 @default.

• next