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• W2122115409 startingPage "937" @default.
• W2122115409 abstract "ABSTRACT Infection of C57BL/6 mice with the moderately virulent Cryptococcus neoformans strain 52D models the complex adaptive immune response observed in HIV-negative patients with persistent fungal lung infections. In this model, Th1 and Th2 responses evolve over time, yet the contribution of interleukin-17A (IL-17A) to antifungal host defense is unknown. In this study, we show that fungal lung infection promoted an increase in Th17 T cells that persisted to 8 weeks postinfection. Our comparison of fungal lung infection in wild-type mice and IL-17A-deficient mice (IL-17A −/− mice; C57BL/6 genetic background) demonstrated that late fungal clearance was impaired in the absence of IL-17A. This finding was associated with reduced intracellular containment of the organism within lung macrophages and deficits in the accumulation of total lung leukocytes, including specific reductions in CD11c + CD11b + myeloid cells (dendritic cells and exudate macrophages), B cells, and CD8 + T cells, and a nonsignificant trend in the reduction of lung neutrophils. Although IL-17A did not alter the total number of CD4 T cells, decreases in the total number of CD4 T cells and CD8 T cells expressing gamma interferon (IFN-γ) were observed in IL-17A −/− mice. Lastly, expression of major histocompatibility complex class II (MHC-II) and the costimulatory molecules CD80 and CD86 on CD11c + CD11b + myeloid cells was diminished in IL-17A −/− mice. Collectively, these data indicate that IL-17A enhances host defenses against a moderately virulent strain of C. neoformans through effects on leukocyte recruitment, IFN-γ production by CD4 and CD8 T cells, and the activation of lung myeloid cells." @default.
• W2122115409 created "2016-06-24" @default.
• W2122115409 creator A5003291506 @default.
• W2122115409 creator A5039544059 @default.
• W2122115409 creator A5044612647 @default.
• W2122115409 creator A5083690478 @default.
• W2122115409 date "2014-03-01" @default.
• W2122115409 modified "2023-09-25" @default.
• W2122115409 title "Interleukin-17A Enhances Host Defense against Cryptococcal Lung Infection through Effects Mediated by Leukocyte Recruitment, Activation, and Gamma Interferon Production" @default.
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• W2122115409 doi "https://doi.org/10.1128/iai.01477-13" @default.
• W2122115409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3957981" @default.
• W2122115409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24324191" @default.
• W2122115409 hasPublicationYear "2014" @default.
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