Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122120273> ?p ?o ?g. }
- W2122120273 endingPage "739" @default.
- W2122120273 startingPage "731" @default.
- W2122120273 abstract "Disintegrins have been previously described in the venom of several snake families inhibiting signal transduction, cell-cell interactions, and cell-matrix interactions and may have therapeutic potential in heart attacks, thrombotic diseases, and cancers. This investigation describes the first disintegrin isolated from South American Crotalus venom (Venezuelan rattlesnake Crotalus durissus cumanensis), which inhibits platelet adhesion to matrix proteins. C. d. cumanensis crude venom was first separated on a Sephadex G-100 column into 4 fractions (SI to SIV). Crude venom and SIII fraction significantly diminished platelet adhesion to fibrinogen (Fg) and to fibronectin (Fn). Anti-adhesive SIII fraction was further separated by DEAE-Sephacel followed by C-18 reverse phase high performance liquid chromatography (HPLC). The platelet anti-adhesive fraction obtained was designated as cumanastatin-1. This disintegrin has a mass of 7.442 kDa as determined by mass spectrometry (MALDI-TOF/TOF) and pI of 8.5. Cumanastatin-1 also inhibited ADP-induced platelet aggregation with an IC50 of 158 nM. However, it did not significantly inhibit collagen and thrombin-induced platelet aggregation. Cumanastatin-1 considerably inhibited anti-αIIbβ3 integrin binding to platelets in a dose-dependent manner; however, it did not present any effect on the α5β1 integrin or on P-selectin." @default.
- W2122120273 created "2016-06-24" @default.
- W2122120273 creator A5012998605 @default.
- W2122120273 creator A5016951436 @default.
- W2122120273 creator A5021210234 @default.
- W2122120273 creator A5028646825 @default.
- W2122120273 creator A5044129370 @default.
- W2122120273 creator A5044223308 @default.
- W2122120273 creator A5065454405 @default.
- W2122120273 creator A5074208002 @default.
- W2122120273 creator A5079147730 @default.
- W2122120273 creator A5084074878 @default.
- W2122120273 date "2009-03-01" @default.
- W2122120273 modified "2023-10-18" @default.
- W2122120273 title "Anti-platelet effect of cumanastatin 1, a disintegrin isolated from venom of South American Crotalus rattlesnake" @default.
- W2122120273 cites W1496621293 @default.
- W2122120273 cites W1509187363 @default.
- W2122120273 cites W151096917 @default.
- W2122120273 cites W1549514523 @default.
- W2122120273 cites W1555943967 @default.
- W2122120273 cites W1608689063 @default.
- W2122120273 cites W1775749144 @default.
- W2122120273 cites W1957982819 @default.
- W2122120273 cites W1967868924 @default.
- W2122120273 cites W1972970439 @default.
- W2122120273 cites W1975085160 @default.
- W2122120273 cites W1978571350 @default.
- W2122120273 cites W1985550180 @default.
- W2122120273 cites W1990946341 @default.
- W2122120273 cites W1995516187 @default.
- W2122120273 cites W2003669563 @default.
- W2122120273 cites W2004439765 @default.
- W2122120273 cites W2011260915 @default.
- W2122120273 cites W201735851 @default.
- W2122120273 cites W2020921331 @default.
- W2122120273 cites W2022595863 @default.
- W2122120273 cites W2023493650 @default.
- W2122120273 cites W2026624464 @default.
- W2122120273 cites W2027387043 @default.
- W2122120273 cites W2029136951 @default.
- W2122120273 cites W2032879069 @default.
- W2122120273 cites W2033677399 @default.
- W2122120273 cites W2037003265 @default.
- W2122120273 cites W2043521254 @default.
- W2122120273 cites W2045166945 @default.
- W2122120273 cites W2050877576 @default.
- W2122120273 cites W2051539953 @default.
- W2122120273 cites W2052818916 @default.
- W2122120273 cites W2058713442 @default.
- W2122120273 cites W2062713415 @default.
- W2122120273 cites W2063790836 @default.
- W2122120273 cites W2070271909 @default.
- W2122120273 cites W2074787208 @default.
- W2122120273 cites W2080866550 @default.
- W2122120273 cites W2092729970 @default.
- W2122120273 cites W2095015904 @default.
- W2122120273 cites W2116153910 @default.
- W2122120273 cites W2122871792 @default.
- W2122120273 cites W2143846950 @default.
- W2122120273 cites W2152174597 @default.
- W2122120273 cites W2154480952 @default.
- W2122120273 cites W2158904285 @default.
- W2122120273 cites W2319736817 @default.
- W2122120273 cites W2415459549 @default.
- W2122120273 cites W2440197793 @default.
- W2122120273 cites W2468148712 @default.
- W2122120273 cites W4206356470 @default.
- W2122120273 cites W4232534952 @default.
- W2122120273 cites W4366064109 @default.
- W2122120273 doi "https://doi.org/10.1016/j.thromres.2008.08.001" @default.
- W2122120273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18835011" @default.
- W2122120273 hasPublicationYear "2009" @default.
- W2122120273 type Work @default.
- W2122120273 sameAs 2122120273 @default.
- W2122120273 citedByCount "29" @default.
- W2122120273 countsByYear W21221202732012 @default.
- W2122120273 countsByYear W21221202732013 @default.
- W2122120273 countsByYear W21221202732014 @default.
- W2122120273 countsByYear W21221202732015 @default.
- W2122120273 countsByYear W21221202732016 @default.
- W2122120273 countsByYear W21221202732017 @default.
- W2122120273 countsByYear W21221202732018 @default.
- W2122120273 countsByYear W21221202732021 @default.
- W2122120273 countsByYear W21221202732022 @default.
- W2122120273 countsByYear W21221202732023 @default.
- W2122120273 crossrefType "journal-article" @default.
- W2122120273 hasAuthorship W2122120273A5012998605 @default.
- W2122120273 hasAuthorship W2122120273A5016951436 @default.
- W2122120273 hasAuthorship W2122120273A5021210234 @default.
- W2122120273 hasAuthorship W2122120273A5028646825 @default.
- W2122120273 hasAuthorship W2122120273A5044129370 @default.
- W2122120273 hasAuthorship W2122120273A5044223308 @default.
- W2122120273 hasAuthorship W2122120273A5065454405 @default.
- W2122120273 hasAuthorship W2122120273A5074208002 @default.
- W2122120273 hasAuthorship W2122120273A5079147730 @default.
- W2122120273 hasAuthorship W2122120273A5084074878 @default.
- W2122120273 hasConcept C1491633281 @default.
- W2122120273 hasConcept C153911025 @default.