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• W2122140147 abstract "In this issue of the Journal, Zagars and colleagues examine the evidence that Gleason grading of prostatic adenocarcinema is an important prognostic factor in the evaluation of patients treated with radiation therapy (56). In a study of 648 patients followed for a mean of 6.5 years after radiation therapy, they found that Gleason tumor grade was the single most important determinant of outcome for clinically localized prostate cancer. They grouped the Gleason scores into four categories, an unusual stratification, and found significant stepwise correlation with survival by univariate and multivariate analyses. In most other studies of outcome and tumor grade, Gleason scores are divided into three groups including Grades 5, 6, and 7 as one group (3,2 1). Using such grouping, most studies show that T stage is of greater prognostic significance than histologic grade evaluated by Gleason score. In this currently published study, where Gleason Grade 7 is separately grouped, tumor grade is shown to be the most important determinant for all endpoints, including local recurrence, distant metastases, any relapse, and overall survival. This result was true in needle biopsy specimens and transurethral resections of prostate, confirming the usefulness and validity of grading needle biopsies. Other investigators found that needle biopsies provide the correct grade in 70% of cases (7, 19). This study confirms those observations. Because most patients are currently diagnosed with needle biopsy of the prostate, these observations have important implications in patient management. Over the past few years, a variety of other potential" @default.
• W2122140147 created "2016-06-24" @default.
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• W2122140147 date "1995-01-01" @default.
• W2122140147 modified "2023-09-27" @default.
• W2122140147 title "Current status of tissue markers as prognostic factors in prostatic adenocarcinoma" @default.
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• W2122140147 doi "https://doi.org/10.1016/0360-3016(94)00582-6" @default.
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