FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122141117> ?p ?o ?g. }

• W2122141117 endingPage "858" @default.
• W2122141117 startingPage "846" @default.
• W2122141117 abstract "RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver. Although the Q/R site within the GluR-B premessage is edited more efficiently by ADAR2 than it is by ADAR1, the converse is true for the +60 site within this same transcript. ADAR1 and ADAR2 are homologs having two common functional regions, an N-terminal double-stranded RNA-binding domain and a C-terminal deaminase domain. It is neither understood why only certain adenosines within a substrate molecule serve as targets for ADARs, nor is it known which domain of an ADAR confers its specificity for particular editing sites. To assess the importance of several aspects of RNA sequence and structure on editing, we evaluated 20 different mutated substrates, derived from four editing sites, for their ability to be edited by either ADAR1 or ADAR2. We found that when these derivatives contained an A:C mismatch at the editing site, editing by both ADARs was enhanced compared to when A:A or A:G mismatches or A:U base pairs occurred at the same site. Hence substrate recognition and/or catalysis by ADARs could involve the base that opposes the edited adenosine. In addition, by using protein chimeras in which the deaminase domains were exchanged between ADAR1 and ADAR2, we found that this domain played a dominant role in defining the substrate specificity of the resulting enzyme." @default.
• W2122141117 created "2016-06-24" @default.
• W2122141117 creator A5028370256 @default.
• W2122141117 creator A5045754791 @default.
• W2122141117 creator A5065626004 @default.
• W2122141117 date "2001-06-01" @default.
• W2122141117 modified "2023-09-30" @default.
• W2122141117 title "Substrate recognition by ADAR1 and ADAR2" @default.
• W2122141117 cites W1495704598 @default.
• W2122141117 cites W1768947898 @default.
• W2122141117 cites W1982848096 @default.
• W2122141117 cites W1986923087 @default.
• W2122141117 cites W1995956654 @default.
• W2122141117 cites W1996063915 @default.
• W2122141117 cites W1998961564 @default.
• W2122141117 cites W2006178602 @default.
• W2122141117 cites W2008476211 @default.
• W2122141117 cites W2012463423 @default.
• W2122141117 cites W2014127990 @default.
• W2122141117 cites W2017472306 @default.
• W2122141117 cites W2018793883 @default.
• W2122141117 cites W2028625367 @default.
• W2122141117 cites W2028711262 @default.
• W2122141117 cites W2029526949 @default.
• W2122141117 cites W2030837160 @default.
• W2122141117 cites W2041199002 @default.
• W2122141117 cites W2046641567 @default.
• W2122141117 cites W2056025481 @default.
• W2122141117 cites W2074562954 @default.
• W2122141117 cites W2080430475 @default.
• W2122141117 cites W2083443360 @default.
• W2122141117 cites W2083787533 @default.
• W2122141117 cites W2084285144 @default.
• W2122141117 cites W2084324934 @default.
• W2122141117 cites W2114379433 @default.
• W2122141117 cites W2117696576 @default.
• W2122141117 cites W2120276739 @default.
• W2122141117 cites W2133435396 @default.
• W2122141117 cites W2136707373 @default.
• W2122141117 cites W2157441620 @default.
• W2122141117 cites W2161048703 @default.
• W2122141117 cites W64310402 @default.
• W2122141117 doi "https://doi.org/10.1017/s135583820101007x" @default.
• W2122141117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1370134" @default.
• W2122141117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11421361" @default.
• W2122141117 hasPublicationYear "2001" @default.
• W2122141117 type Work @default.
• W2122141117 sameAs 2122141117 @default.
• W2122141117 citedByCount "197" @default.
• W2122141117 countsByYear W21221411172012 @default.
• W2122141117 countsByYear W21221411172013 @default.
• W2122141117 countsByYear W21221411172014 @default.
• W2122141117 countsByYear W21221411172015 @default.
• W2122141117 countsByYear W21221411172016 @default.
• W2122141117 countsByYear W21221411172017 @default.
• W2122141117 countsByYear W21221411172018 @default.
• W2122141117 countsByYear W21221411172019 @default.
• W2122141117 countsByYear W21221411172020 @default.
• W2122141117 countsByYear W21221411172021 @default.
• W2122141117 countsByYear W21221411172022 @default.
• W2122141117 countsByYear W21221411172023 @default.
• W2122141117 crossrefType "journal-article" @default.
• W2122141117 hasAuthorship W2122141117A5028370256 @default.
• W2122141117 hasAuthorship W2122141117A5045754791 @default.
• W2122141117 hasAuthorship W2122141117A5065626004 @default.
• W2122141117 hasBestOaLocation W21221411172 @default.
• W2122141117 hasConcept C104317684 @default.
• W2122141117 hasConcept C107824862 @default.
• W2122141117 hasConcept C21786251 @default.
• W2122141117 hasConcept C2776991684 @default.
• W2122141117 hasConcept C2777610669 @default.
• W2122141117 hasConcept C2778323267 @default.
• W2122141117 hasConcept C34628245 @default.
• W2122141117 hasConcept C41282012 @default.
• W2122141117 hasConcept C55493867 @default.
• W2122141117 hasConcept C67705224 @default.
• W2122141117 hasConcept C70721500 @default.
• W2122141117 hasConcept C86803240 @default.
• W2122141117 hasConceptScore W2122141117C104317684 @default.
• W2122141117 hasConceptScore W2122141117C107824862 @default.
• W2122141117 hasConceptScore W2122141117C21786251 @default.
• W2122141117 hasConceptScore W2122141117C2776991684 @default.
• W2122141117 hasConceptScore W2122141117C2777610669 @default.
• W2122141117 hasConceptScore W2122141117C2778323267 @default.
• W2122141117 hasConceptScore W2122141117C34628245 @default.
• W2122141117 hasConceptScore W2122141117C41282012 @default.
• W2122141117 hasConceptScore W2122141117C55493867 @default.
• W2122141117 hasConceptScore W2122141117C67705224 @default.
• W2122141117 hasConceptScore W2122141117C70721500 @default.
• W2122141117 hasConceptScore W2122141117C86803240 @default.
• W2122141117 hasIssue "6" @default.
• W2122141117 hasLocation W21221411171 @default.
• W2122141117 hasLocation W21221411172 @default.
• W2122141117 hasLocation W21221411173 @default.
• W2122141117 hasLocation W21221411174 @default.
• W2122141117 hasOpenAccess W2122141117 @default.
• W2122141117 hasPrimaryLocation W21221411171 @default.
• W2122141117 hasRelatedWork W1790230890 @default.

• next