FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122142425> ?p ?o ?g. }

• W2122142425 endingPage "638" @default.
• W2122142425 startingPage "631" @default.
• W2122142425 abstract "Primordial germ cells (PGCs) are undifferentiated germ cells in developing fetuses. As these cells give rise to definitive oocytes and spermatozoa that contribute to new life in the next generation, their development must be under strict control, regarding genetic and epigenetic aspects. However, we do not know to what extent their development depends on the specific milieu. In this study, we transplanted mouse PGCs collected from male and female gonads at 12.5 days postcoitum, together with gonadal somatic cells, under kidney capsules of adult mice. The transplanted PGC and gonadal somatic cells constructed testis-like and ovary-like tissues, respectively, under the kidney capsules within 4 wk. Normal-appearing round spermatids and fully grown germinal vesicle (GV) oocytes developed within these tissues. Ectopic spermatogenesis continued thereafter, while oogenesis consisted of only a single wave. The injection of these round spermatids directly into mature in vivo-derived oocytes led to the birth at term of normal pups. PGC-derived GV oocytes were isolated, induced to mature in vitro, and injected with normal spermatozoa. The injected oocytes were successfully fertilized and developed into normal pups. Our findings demonstrate the remarkable flexibility of PGC development, which can proceed up to the functional gamete stage under spatially and temporally noninnate conditions. This transplantation system may provide a unique technical basis for induction of the development of early germ cells of exogenous origins, such as those from embryonic stem cells." @default.
• W2122142425 created "2016-06-24" @default.
• W2122142425 creator A5031145281 @default.
• W2122142425 creator A5067253013 @default.
• W2122142425 date "2010-11-10" @default.
• W2122142425 modified "2023-10-10" @default.
• W2122142425 title "Generation of Functional Oocytes and Spermatids from Fetal Primordial Germ Cells after Ectopic Transplantation in Adult Mice" @default.
• W2122142425 cites W1487014009 @default.
• W2122142425 cites W1572198832 @default.
• W2122142425 cites W1970506768 @default.
• W2122142425 cites W1976435237 @default.
• W2122142425 cites W2005958031 @default.
• W2122142425 cites W2015874753 @default.
• W2122142425 cites W2016789158 @default.
• W2122142425 cites W2017959909 @default.
• W2122142425 cites W2018221132 @default.
• W2122142425 cites W2023044209 @default.
• W2122142425 cites W2023108126 @default.
• W2122142425 cites W2032199894 @default.
• W2122142425 cites W2032811891 @default.
• W2122142425 cites W2041288808 @default.
• W2122142425 cites W2048762145 @default.
• W2122142425 cites W2057836896 @default.
• W2122142425 cites W2061361108 @default.
• W2122142425 cites W2077886867 @default.
• W2122142425 cites W2078705189 @default.
• W2122142425 cites W2094722357 @default.
• W2122142425 cites W2099946828 @default.
• W2122142425 cites W2118155100 @default.
• W2122142425 cites W2135676525 @default.
• W2122142425 cites W2138292740 @default.
• W2122142425 cites W2143845540 @default.
• W2122142425 cites W2148661975 @default.
• W2122142425 cites W2155416471 @default.
• W2122142425 cites W2155610056 @default.
• W2122142425 cites W2164359007 @default.
• W2122142425 cites W2166919456 @default.
• W2122142425 cites W2413268869 @default.
• W2122142425 cites W3020868922 @default.
• W2122142425 cites W39364543 @default.
• W2122142425 cites W2057515238 @default.
• W2122142425 doi "https://doi.org/10.1095/biolreprod.110.087122" @default.
• W2122142425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21076079" @default.
• W2122142425 hasPublicationYear "2010" @default.
• W2122142425 type Work @default.
• W2122142425 sameAs 2122142425 @default.
• W2122142425 citedByCount "62" @default.
• W2122142425 countsByYear W21221424252012 @default.
• W2122142425 countsByYear W21221424252013 @default.
• W2122142425 countsByYear W21221424252014 @default.
• W2122142425 countsByYear W21221424252015 @default.
• W2122142425 countsByYear W21221424252016 @default.
• W2122142425 countsByYear W21221424252017 @default.
• W2122142425 countsByYear W21221424252018 @default.
• W2122142425 countsByYear W21221424252019 @default.
• W2122142425 countsByYear W21221424252020 @default.
• W2122142425 countsByYear W21221424252021 @default.
• W2122142425 countsByYear W21221424252022 @default.
• W2122142425 countsByYear W21221424252023 @default.
• W2122142425 crossrefType "journal-article" @default.
• W2122142425 hasAuthorship W2122142425A5031145281 @default.
• W2122142425 hasAuthorship W2122142425A5067253013 @default.
• W2122142425 hasBestOaLocation W21221424251 @default.
• W2122142425 hasConcept C104317684 @default.
• W2122142425 hasConcept C109825262 @default.
• W2122142425 hasConcept C123765429 @default.
• W2122142425 hasConcept C126322002 @default.
• W2122142425 hasConcept C134018914 @default.
• W2122142425 hasConcept C134305767 @default.
• W2122142425 hasConcept C163949779 @default.
• W2122142425 hasConcept C16685009 @default.
• W2122142425 hasConcept C196843134 @default.
• W2122142425 hasConcept C2776690073 @default.
• W2122142425 hasConcept C2779122487 @default.
• W2122142425 hasConcept C2911091166 @default.
• W2122142425 hasConcept C2994119143 @default.
• W2122142425 hasConcept C39297687 @default.
• W2122142425 hasConcept C54355233 @default.
• W2122142425 hasConcept C71924100 @default.
• W2122142425 hasConcept C86803240 @default.
• W2122142425 hasConcept C87073359 @default.
• W2122142425 hasConcept C95444343 @default.
• W2122142425 hasConceptScore W2122142425C104317684 @default.
• W2122142425 hasConceptScore W2122142425C109825262 @default.
• W2122142425 hasConceptScore W2122142425C123765429 @default.
• W2122142425 hasConceptScore W2122142425C126322002 @default.
• W2122142425 hasConceptScore W2122142425C134018914 @default.
• W2122142425 hasConceptScore W2122142425C134305767 @default.
• W2122142425 hasConceptScore W2122142425C163949779 @default.
• W2122142425 hasConceptScore W2122142425C16685009 @default.
• W2122142425 hasConceptScore W2122142425C196843134 @default.
• W2122142425 hasConceptScore W2122142425C2776690073 @default.
• W2122142425 hasConceptScore W2122142425C2779122487 @default.
• W2122142425 hasConceptScore W2122142425C2911091166 @default.
• W2122142425 hasConceptScore W2122142425C2994119143 @default.
• W2122142425 hasConceptScore W2122142425C39297687 @default.
• W2122142425 hasConceptScore W2122142425C54355233 @default.
• W2122142425 hasConceptScore W2122142425C71924100 @default.

• next