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- W2122152063 abstract "Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the bone marrow and the blood. Key extracellular regulatory elements for this process have been defined (cell-cell adhesion, growth factors, chemokines), but the mechanism by which HSC/P cells reconcile multiple external signals has not been elucidated. Rac and related small GTPases are candidates for this role and were studied in HSC/P deficient in Rac2, a hematopoietic cell-specific family member. Rac2 appears to be critical for HSC/P adhesion both in vitro and in vivo, whereas a compensatory increase in Cdc42 activation regulates HSC/P migration. This genetic analysis provides physiological evidence of cross-talk between GTPase proteins and suggests that a balance of these two GTPases controls HSC/P adhesion and mobilization in vivo." @default.
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- W2122152063 date "2001-04-24" @default.
- W2122152063 modified "2023-10-03" @default.
- W2122152063 title "Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization" @default.
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- W2122152063 doi "https://doi.org/10.1073/pnas.101546898" @default.
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