FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122160136> ?p ?o ?g. }

• W2122160136 endingPage "6349" @default.
• W2122160136 startingPage "6345" @default.
• W2122160136 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide belonging to the vasoactive intestinal peptide (VIP)/secretion/glucagon family of peptides, interacts with a distinct high-affinity receptor (type I receptor) on a number of tissues. These PACAP type I receptors have a high affinity for PACAP and a low affinity for VIP and are present in the hypothalamus and anterior pituitary, where they regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, and prolactin, and in the adrenal medulla, where they regulate the release of epinephrine. Type I PACAP receptors are also present in high concentrations in testicular germ cells, where they may regulate spermatogenesis, and some transformed cell lines, such as the rat pancreatic acinar carcinoma cell AR4-2J. Here we report the molecular cloning and functional expression of the PACAP type I receptor isolated from an AR4-2J cell cDNA library by cross-hybridization screening with a rat VIP receptor cDNA. The cDNA sequence encodes a unique 495-amino acid protein with seven transmembrane domains characteristic of guanine nucleotide-binding regulatory protein-coupled receptors. A high degree of sequence homology with the VIP, secretin, glucagon-like peptide 1, parathyroid, and calcitonin receptors suggests its membership in this subfamily of Gs-coupled receptors. Results of binding studies and stimulation of cellular cAMP accumulation in COS-7 cells transfected with this cDNA are characteristic of a PACAP type I receptor. Cloning of the PACAP type I receptor will enhance our understanding of its distribution, structure, and functional properties and ultimately increase our understanding of its physiological role." @default.
• W2122160136 created "2016-06-24" @default.
• W2122160136 creator A5010634985 @default.
• W2122160136 creator A5020411590 @default.
• W2122160136 date "1993-07-01" @default.
• W2122160136 modified "2023-10-13" @default.
• W2122160136 title "Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor." @default.
• W2122160136 cites W1546570611 @default.
• W2122160136 cites W1560293757 @default.
• W2122160136 cites W1766643663 @default.
• W2122160136 cites W1799683217 @default.
• W2122160136 cites W1964761526 @default.
• W2122160136 cites W1965963242 @default.
• W2122160136 cites W1966819735 @default.
• W2122160136 cites W1975304761 @default.
• W2122160136 cites W1975517228 @default.
• W2122160136 cites W1981423842 @default.
• W2122160136 cites W1988298211 @default.
• W2122160136 cites W1988298653 @default.
• W2122160136 cites W1988646125 @default.
• W2122160136 cites W1989201786 @default.
• W2122160136 cites W1992104129 @default.
• W2122160136 cites W1993301425 @default.
• W2122160136 cites W1993620919 @default.
• W2122160136 cites W2000181594 @default.
• W2122160136 cites W2001439970 @default.
• W2122160136 cites W2004129966 @default.
• W2122160136 cites W2009310436 @default.
• W2122160136 cites W2014669590 @default.
• W2122160136 cites W2018159284 @default.
• W2122160136 cites W2023706785 @default.
• W2122160136 cites W2024948700 @default.
• W2122160136 cites W2036008616 @default.
• W2122160136 cites W2037248591 @default.
• W2122160136 cites W2047523044 @default.
• W2122160136 cites W2048183867 @default.
• W2122160136 cites W2069280775 @default.
• W2122160136 cites W2074501705 @default.
• W2122160136 cites W2083176073 @default.
• W2122160136 cites W2094407013 @default.
• W2122160136 cites W2095045173 @default.
• W2122160136 cites W2103569380 @default.
• W2122160136 cites W2113630547 @default.
• W2122160136 cites W2129137786 @default.
• W2122160136 cites W2138270253 @default.
• W2122160136 cites W2138879032 @default.
• W2122160136 cites W2156837840 @default.
• W2122160136 cites W2160088320 @default.
• W2122160136 cites W2170767170 @default.
• W2122160136 cites W2396394505 @default.
• W2122160136 cites W245031103 @default.
• W2122160136 doi "https://doi.org/10.1073/pnas.90.13.6345" @default.
• W2122160136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/46925" @default.
• W2122160136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8392197" @default.
• W2122160136 hasPublicationYear "1993" @default.
• W2122160136 type Work @default.
• W2122160136 sameAs 2122160136 @default.
• W2122160136 citedByCount "334" @default.
• W2122160136 countsByYear W21221601362012 @default.
• W2122160136 countsByYear W21221601362013 @default.
• W2122160136 countsByYear W21221601362014 @default.
• W2122160136 countsByYear W21221601362015 @default.
• W2122160136 countsByYear W21221601362016 @default.
• W2122160136 countsByYear W21221601362017 @default.
• W2122160136 countsByYear W21221601362018 @default.
• W2122160136 countsByYear W21221601362019 @default.
• W2122160136 countsByYear W21221601362020 @default.
• W2122160136 countsByYear W21221601362021 @default.
• W2122160136 countsByYear W21221601362022 @default.
• W2122160136 countsByYear W21221601362023 @default.
• W2122160136 crossrefType "journal-article" @default.
• W2122160136 hasAuthorship W2122160136A5010634985 @default.
• W2122160136 hasAuthorship W2122160136A5020411590 @default.
• W2122160136 hasBestOaLocation W21221601361 @default.
• W2122160136 hasConcept C117156480 @default.
• W2122160136 hasConcept C118303440 @default.
• W2122160136 hasConcept C134018914 @default.
• W2122160136 hasConcept C135285700 @default.
• W2122160136 hasConcept C153911025 @default.
• W2122160136 hasConcept C170493617 @default.
• W2122160136 hasConcept C2778677841 @default.
• W2122160136 hasConcept C49039625 @default.
• W2122160136 hasConcept C55493867 @default.
• W2122160136 hasConcept C8330315 @default.
• W2122160136 hasConcept C86803240 @default.
• W2122160136 hasConceptScore W2122160136C117156480 @default.
• W2122160136 hasConceptScore W2122160136C118303440 @default.
• W2122160136 hasConceptScore W2122160136C134018914 @default.
• W2122160136 hasConceptScore W2122160136C135285700 @default.
• W2122160136 hasConceptScore W2122160136C153911025 @default.
• W2122160136 hasConceptScore W2122160136C170493617 @default.
• W2122160136 hasConceptScore W2122160136C2778677841 @default.
• W2122160136 hasConceptScore W2122160136C49039625 @default.
• W2122160136 hasConceptScore W2122160136C55493867 @default.
• W2122160136 hasConceptScore W2122160136C8330315 @default.
• W2122160136 hasConceptScore W2122160136C86803240 @default.
• W2122160136 hasIssue "13" @default.
• W2122160136 hasLocation W21221601361 @default.

• next