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• W2122168420 startingPage "3402" @default.
• W2122168420 abstract "Saccharomyces cerevisiae Cin8p belongs to the BimC family of kinesin-related motor proteins that are essential for spindle assembly. Cin8p levels were found to oscillate in the cell cycle due in part to a high rate of degradation imposed from the end of mitosis through the G1 phase. Cin8p degradation required the anaphase-promoting complex ubiquitin ligase and its late mitosis regulator Cdh1p but not the early mitosis regulator Cdc20p. Cin8p lacks a functional destruction box sequence that is found in the majority of anaphase-promoting complex substrates. We carried out an extensive mutagenesis study to define the cis-acting sequence required for Cin8p degradation in vivo. The C terminus of Cin8p contains two elements required for its degradation: 1) a bipartite destruction sequence composed of a KEN-box plus essential residues within the downstream 22 amino acids and 2) a nuclear localization signal. The bipartite destruction sequence appears in other BimC kinesins as well. Expression of nondegradable Cin8p showed very mild phenotypic effects, with an increase in the fraction of mitotic cells with broken spindles." @default.
• W2122168420 created "2016-06-24" @default.
• W2122168420 creator A5013794253 @default.
• W2122168420 creator A5067442390 @default.
• W2122168420 date "2001-11-01" @default.
• W2122168420 modified "2023-10-11" @default.
• W2122168420 title "Cell Cycle-dependent Degradation of the<i>Saccharomyces cerevisiae</i>Spindle Motor Cin8p Requires APC^Cdh1and a Bipartite Destruction Sequence" @default.
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• W2122168420 doi "https://doi.org/10.1091/mbc.12.11.3402" @default.
• W2122168420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60263" @default.
• W2122168420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11694576" @default.
• W2122168420 hasPublicationYear "2001" @default.
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