Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122168568> ?p ?o ?g. }
- W2122168568 endingPage "36" @default.
- W2122168568 startingPage "25" @default.
- W2122168568 abstract "Ghrelin is a circulating orexigenic signal that rises with prolonged fasting and falls postprandially. Ghrelin regulates energy homeostasis by stimulating appetite and body weight; however, it also has many nonmetabolic functions including enhanced learning and memory, anxiolytic effects as well as being neuroprotective. In Parkinson’s disease, ghrelin enhances dopaminergic survival via reduced microglial and caspase activation and improved mitochondrial function. As mitochondrial dysfunction contributes to Parkinson’s disease, any agent that enhances mitochondrial function could be a potential therapeutic target. We propose that ghrelin provides neuroprotective effects via AMPK (5′ adenosine monophosphate-activated protein kinase) activation and enhanced mitophagy (removal of damaged mitochondria) to ultimately enhance mitochondrial bioenergetics. AMPK activation shifts energy balance from a negative to a neutral state and has a role in regulating mitochondrial biogenesis and reducing reactive oxygen species production. Mitophagy is important in Parkinson’s disease because damaged mitochondria produce reactive oxygen species resulting in damage to intracellular proteins, lipids and DNA predisposing them to neurodegeneration. Many genetic mutations linked to Parkinson’s disease are due to abnormal mitochondrial function and mitophagy, for example LRRK2, PINK1 and Parkin. An interaction between ghrelin and these classic Parkinson’s disease markers has not been observed, however by enhancing mitochondrial function, ghrelin or AMPK is a potential therapeutic target for slowing the progression of Parkinson’s disease symptoms, both motor and nonmotor." @default.
- W2122168568 created "2016-06-24" @default.
- W2122168568 creator A5007604702 @default.
- W2122168568 creator A5088688793 @default.
- W2122168568 date "2013-02-01" @default.
- W2122168568 modified "2023-10-02" @default.
- W2122168568 title "Ghrelin is neuroprotective in Parkinson’s disease: molecular mechanisms of metabolic neuroprotection" @default.
- W2122168568 cites W1531537085 @default.
- W2122168568 cites W1548033063 @default.
- W2122168568 cites W1562357843 @default.
- W2122168568 cites W1568960993 @default.
- W2122168568 cites W1637971961 @default.
- W2122168568 cites W1877873625 @default.
- W2122168568 cites W1965681020 @default.
- W2122168568 cites W1966132436 @default.
- W2122168568 cites W1967779656 @default.
- W2122168568 cites W1970637701 @default.
- W2122168568 cites W1971692114 @default.
- W2122168568 cites W1976316003 @default.
- W2122168568 cites W1988254695 @default.
- W2122168568 cites W1988803699 @default.
- W2122168568 cites W1989149919 @default.
- W2122168568 cites W1990937715 @default.
- W2122168568 cites W1991742828 @default.
- W2122168568 cites W1992371392 @default.
- W2122168568 cites W1992483894 @default.
- W2122168568 cites W1996611755 @default.
- W2122168568 cites W1997920782 @default.
- W2122168568 cites W1999292282 @default.
- W2122168568 cites W1999828495 @default.
- W2122168568 cites W2002514583 @default.
- W2122168568 cites W2003321861 @default.
- W2122168568 cites W2009845708 @default.
- W2122168568 cites W2010419244 @default.
- W2122168568 cites W2010566714 @default.
- W2122168568 cites W2010858154 @default.
- W2122168568 cites W2015037392 @default.
- W2122168568 cites W2016752484 @default.
- W2122168568 cites W2016905315 @default.
- W2122168568 cites W2018127398 @default.
- W2122168568 cites W2018427433 @default.
- W2122168568 cites W2022267544 @default.
- W2122168568 cites W2026946582 @default.
- W2122168568 cites W2032297237 @default.
- W2122168568 cites W2033729587 @default.
- W2122168568 cites W2040509326 @default.
- W2122168568 cites W2040605398 @default.
- W2122168568 cites W2042706232 @default.
- W2122168568 cites W2045123689 @default.
- W2122168568 cites W2046885195 @default.
- W2122168568 cites W2049612563 @default.
- W2122168568 cites W2050647292 @default.
- W2122168568 cites W2051773180 @default.
- W2122168568 cites W2054107031 @default.
- W2122168568 cites W2059971906 @default.
- W2122168568 cites W2060127547 @default.
- W2122168568 cites W2062344501 @default.
- W2122168568 cites W2064730183 @default.
- W2122168568 cites W2065216166 @default.
- W2122168568 cites W2067273260 @default.
- W2122168568 cites W2073361547 @default.
- W2122168568 cites W2077343693 @default.
- W2122168568 cites W2079557780 @default.
- W2122168568 cites W2082629592 @default.
- W2122168568 cites W2083560906 @default.
- W2122168568 cites W2084708023 @default.
- W2122168568 cites W2085518652 @default.
- W2122168568 cites W2085946360 @default.
- W2122168568 cites W2087360216 @default.
- W2122168568 cites W2090644845 @default.
- W2122168568 cites W2091540906 @default.
- W2122168568 cites W2096905204 @default.
- W2122168568 cites W2097989918 @default.
- W2122168568 cites W2099269836 @default.
- W2122168568 cites W2099547258 @default.
- W2122168568 cites W2106444069 @default.
- W2122168568 cites W2111682630 @default.
- W2122168568 cites W2114349736 @default.
- W2122168568 cites W2115651249 @default.
- W2122168568 cites W2116605894 @default.
- W2122168568 cites W2122828560 @default.
- W2122168568 cites W2124458011 @default.
- W2122168568 cites W2124780869 @default.
- W2122168568 cites W2126478464 @default.
- W2122168568 cites W2128018781 @default.
- W2122168568 cites W2131409719 @default.
- W2122168568 cites W2133184469 @default.
- W2122168568 cites W2133444149 @default.
- W2122168568 cites W2140808124 @default.
- W2122168568 cites W2141677575 @default.
- W2122168568 cites W2142483035 @default.
- W2122168568 cites W2143711558 @default.
- W2122168568 cites W2143800493 @default.
- W2122168568 cites W2149581216 @default.
- W2122168568 cites W2149686779 @default.
- W2122168568 cites W2152165298 @default.
- W2122168568 cites W2154294326 @default.
- W2122168568 cites W2154737306 @default.