FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122172764> ?p ?o ?g. }

• W2122172764 endingPage "5830" @default.
• W2122172764 startingPage "5826" @default.
• W2122172764 abstract "Retinoic acid is one of the most promising drugs for chemotherapy and chemoprevention of cancer. Either blocking activator protein-1 (AP-1) activity or activating retinoic acid response element (RARE) have been proposed to be responsible for its antitumor activity. However, evidence for this hypothesis is lacking in vivo studies. To address this issue, we used an AP-1-luciferase transgenic mouse as a carcinogenesis model and new synthetic retinoids that are either selective inhibitors of AP-1 activation or selective activators of the RARE. The results showed that the SR11302, an AP-1 inhibition-specific retinoid, and other AP-1 inhibitors such as trans-retinoic acid and fluocinolone acetonide, markedly inhibit both 12- O -tetradecanoylphorbol-13-acetate-induced papilloma formation and AP-1 activation in 7,12-dimethyl benz(a)anthracene-initiated mouse skin ( P < 0.05). In contrast, repeated applications of SR11235, a retinoid with RARE transactivating activity, but devoid of AP-1 inhibiting effect, did not cause significant inhibition of papilloma formation and AP-1 activation ( P > 0.05). These results provide the first in vivo evidence that the antitumor effect of retinoids is mediated by blocking AP-1 activity, but not by activation of RARE." @default.
• W2122172764 created "2016-06-24" @default.
• W2122172764 creator A5005383718 @default.
• W2122172764 creator A5025062503 @default.
• W2122172764 creator A5036320286 @default.
• W2122172764 creator A5051208328 @default.
• W2122172764 creator A5055901299 @default.
• W2122172764 creator A5074636897 @default.
• W2122172764 date "1997-05-27" @default.
• W2122172764 modified "2023-10-12" @default.
• W2122172764 title "Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid" @default.
• W2122172764 cites W1516259788 @default.
• W2122172764 cites W1553793186 @default.
• W2122172764 cites W1554600230 @default.
• W2122172764 cites W161204493 @default.
• W2122172764 cites W1617897652 @default.
• W2122172764 cites W1767150122 @default.
• W2122172764 cites W1812437736 @default.
• W2122172764 cites W1849269729 @default.
• W2122172764 cites W1933696045 @default.
• W2122172764 cites W1959523209 @default.
• W2122172764 cites W1966165057 @default.
• W2122172764 cites W1967004332 @default.
• W2122172764 cites W1971624992 @default.
• W2122172764 cites W1983578591 @default.
• W2122172764 cites W1984509210 @default.
• W2122172764 cites W1987453246 @default.
• W2122172764 cites W1987897953 @default.
• W2122172764 cites W1993503942 @default.
• W2122172764 cites W2000905327 @default.
• W2122172764 cites W2002992087 @default.
• W2122172764 cites W2009379675 @default.
• W2122172764 cites W2022891913 @default.
• W2122172764 cites W2030488757 @default.
• W2122172764 cites W2037753946 @default.
• W2122172764 cites W2041270901 @default.
• W2122172764 cites W2042479492 @default.
• W2122172764 cites W2051830689 @default.
• W2122172764 cites W2053131171 @default.
• W2122172764 cites W2058703787 @default.
• W2122172764 cites W2072233737 @default.
• W2122172764 cites W2075118849 @default.
• W2122172764 cites W2081833057 @default.
• W2122172764 cites W2084960544 @default.
• W2122172764 cites W2092237565 @default.
• W2122172764 cites W2097483036 @default.
• W2122172764 cites W2120818551 @default.
• W2122172764 cites W2145087519 @default.
• W2122172764 cites W2168731357 @default.
• W2122172764 cites W2217210743 @default.
• W2122172764 cites W2258484950 @default.
• W2122172764 cites W2406069463 @default.
• W2122172764 cites W4240953228 @default.
• W2122172764 doi "https://doi.org/10.1073/pnas.94.11.5826" @default.
• W2122172764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/20865" @default.
• W2122172764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9159159" @default.
• W2122172764 hasPublicationYear "1997" @default.
• W2122172764 type Work @default.
• W2122172764 sameAs 2122172764 @default.
• W2122172764 citedByCount "207" @default.
• W2122172764 countsByYear W21221727642012 @default.
• W2122172764 countsByYear W21221727642013 @default.
• W2122172764 countsByYear W21221727642014 @default.
• W2122172764 countsByYear W21221727642015 @default.
• W2122172764 countsByYear W21221727642016 @default.
• W2122172764 countsByYear W21221727642017 @default.
• W2122172764 countsByYear W21221727642018 @default.
• W2122172764 countsByYear W21221727642019 @default.
• W2122172764 countsByYear W21221727642020 @default.
• W2122172764 countsByYear W21221727642021 @default.
• W2122172764 countsByYear W21221727642022 @default.
• W2122172764 countsByYear W21221727642023 @default.
• W2122172764 crossrefType "journal-article" @default.
• W2122172764 hasAuthorship W2122172764A5005383718 @default.
• W2122172764 hasAuthorship W2122172764A5025062503 @default.
• W2122172764 hasAuthorship W2122172764A5036320286 @default.
• W2122172764 hasAuthorship W2122172764A5051208328 @default.
• W2122172764 hasAuthorship W2122172764A5055901299 @default.
• W2122172764 hasAuthorship W2122172764A5074636897 @default.
• W2122172764 hasBestOaLocation W21221727642 @default.
• W2122172764 hasConcept C104317684 @default.
• W2122172764 hasConcept C150903083 @default.
• W2122172764 hasConcept C170493617 @default.
• W2122172764 hasConcept C185592680 @default.
• W2122172764 hasConcept C207001950 @default.
• W2122172764 hasConcept C2775954498 @default.
• W2122172764 hasConcept C2778938436 @default.
• W2122172764 hasConcept C2779963572 @default.
• W2122172764 hasConcept C2780122803 @default.
• W2122172764 hasConcept C2781121885 @default.
• W2122172764 hasConcept C502942594 @default.
• W2122172764 hasConcept C55493867 @default.
• W2122172764 hasConcept C555283112 @default.
• W2122172764 hasConcept C86803240 @default.
• W2122172764 hasConcept C88045685 @default.
• W2122172764 hasConcept C98274493 @default.
• W2122172764 hasConceptScore W2122172764C104317684 @default.
• W2122172764 hasConceptScore W2122172764C150903083 @default.

• next