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- W2122173685 abstract "Dendritic cells (DCs) are key regulators of both innate and adaptive immunity. During infection, DCs recognise pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs) including the Toll-like receptor (TLR) family. TLRs mainly signal via the adaptor protein MyD88. This signalling pathway is required for immune protection during many infections, which are lethal in the absence of MyD88. However, the cell type specific importance of this pathway during both innate and adaptive immune responses against pathogens in vivo remains ill-defined. We discuss recent findings from conditional KO or gain-of-function mouse models targeting TLR/MyD88 signalling pathways in DCs and other myeloid cells during infection. While the general assumption that MyD88-dependent recognition by DCs is essential for inducing protective immunity holds true in some instances, the results surprisingly indicate a much more complex context-dependent requirement for this pathway in DCs and other myeloid or lymphoid cell-types in vivo. Furthermore, we highlight the advantages of Cre-mediated DC targeting approaches and their possible limitations. We also present future perspectives on the development of new genetic mouse models to target distinct DC subsets in vivo. Such models will serve to understand the functional heterogeneity of DCs in vivo." @default.
- W2122173685 created "2016-06-24" @default.
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- W2122173685 creator A5012368849 @default.
- W2122173685 creator A5062073102 @default.
- W2122173685 date "2014-12-16" @default.
- W2122173685 modified "2023-10-12" @default.
- W2122173685 title "Dendritic cell specific targeting of MyD88 signalling pathways in vivo" @default.
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- W2122173685 doi "https://doi.org/10.1002/eji.201444747" @default.
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