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• W2122179621 startingPage "987" @default.
• W2122179621 abstract "Abstract Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor. (Cancer Epidemiol Biomarkers Prev 2008;17(4):987–9)" @default.
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• W2122179621 date "2008-04-01" @default.
• W2122179621 modified "2023-10-16" @default.
• W2122179621 title "The Common D302H Variant of CASP8 Is Associated with Risk of Glioma" @default.
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• W2122179621 doi "https://doi.org/10.1158/1055-9965.epi-07-2807" @default.
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