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- W2122193579 endingPage "78" @default.
- W2122193579 startingPage "49" @default.
- W2122193579 abstract "Telomere biology plays a critical and complex role in the initiation and progression of cancer. Although telomere dysfunction resulting from replicative attrition constrains tumor growth by engaging DNA-damage signaling pathways, it can also promote tumorigenesis by causing oncogenic chromosomal rearrangements. Expression of the telomerase enzyme enables telomere-length homeostasis and allows tumor cells to escape the antiproliferative barrier posed by short telomeres. Telomeres and telomerase also function independently of one another. Recent work has suggested that telomerase promotes cell growth through pathways unrelated to telomere maintenance, and a subset of tumors elongate telomeres through telomerase-independent mechanisms. In an effort to exploit the integral link between telomere biology and cancer growth, investigators have developed several telomerase-based therapeutic strategies, which are currently in clinical trials. Here, we broadly review the state of the field with a particular focus on recent developments of interest." @default.
- W2122193579 created "2016-06-24" @default.
- W2122193579 creator A5012280214 @default.
- W2122193579 creator A5041474903 @default.
- W2122193579 creator A5066525634 @default.
- W2122193579 date "2013-01-24" @default.
- W2122193579 modified "2023-10-16" @default.
- W2122193579 title "The Role of Telomere Biology in Cancer" @default.
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