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• W2122245990 abstract "311 Introduction. In vitro activated B cells (aBs) and resting B cells (rBs) are thought to be competent and incompetent antigen-presenting cells (APCs), respectively. aBs can stimulate proliferation of allogeneic T cells and the generation of allo-specific cytotoxic T cells whereas rBs cannot. In marked contrast, in vivo neither donor rBs nor aBs were able to prolong the survival of cardiac grafts mismatched for major histocompatibility complex (MHC) antigens. We reasoned that donor antigen presented by recipient APCs in particular B cells (indirect presentation) might induce graft rejection and overwhelm the potentially tolerogenic effects of direct presentation by donor rBs. Therefore, we used depleting anti-IgD monoclonal antibody (mAb) specific for recipient B cells to decrease the potential of indirect presentation via this route. Methods. rBs were made from spleen using anti-CD4 and CD8 mAbs and complement lysis, Sephadex G-10 columns and a Percoll gradient. aBs were prepared by LPS activation of rBs for 2 days. Hearts from C57BL/10(H2b) mice were transplanted into CBA (H2k) recipients. Mice were pretreated intravenously with 1×107 donor (C57BL/10) rBs or aBs in the presence or absence of 100μg depleting anti-IgD mAb 7 days before grafting. The anti-IgD mAb depletes B cells of recipient but not donor type which are different of allotypic specificity. Results. Naive CBA mice rejected C57BL/10 grafts acutely (MST = 8 days). Pretreatment with rBs and aBs showed minimal prolongation of grafts(MST = 12 and 11 days, respectively). In marked contrast, when delivered with anti-IgD mAb, rBs induced indefinite graft prolongation for over 100 days in all recipients. However, aBs were less effective at inducing graft prolongation than rBs when delivered with anti-IgD mAb (MST = 15 days). Anti-IgD mAb alone induced rejection acutely (MST = 8 days). Conclusion. Depleting anti-IgD mAb (specific for recipient B cells) augmented the ability of donor rBs to induce indefinite prolongation of fully allogeneic cardiac grafts." @default.
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• W2122245990 date "1998-05-01" @default.
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• W2122245990 title "Donor Resting B Cells Induce Indefinite Prolongation of Fully Allogeneic Cardiac Grafts When Delivered with Anti-IgD Monoclonal Antibody" @default.
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• W2122245990 doi "https://doi.org/10.1097/00007890-199805131-00309" @default.
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