Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122265029> ?p ?o ?g. }
- W2122265029 endingPage "3243" @default.
- W2122265029 startingPage "3235" @default.
- W2122265029 abstract "Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal methionine strengthens end-to-end bonds, which enhances actin binding as well as the ability of Tm to regulate myosin motor activity in both muscle and non-muscle cells. In this study we explore the function of each Tm form within fission yeast cells. Electron microscopy and live cell imaging revealed that acetylated and unacetylated Tm associate with distinct actin structures within the cell, and that each form has a profound effect upon the shape and integrity of the polymeric actin filament. We show that, whereas Tm acetylation is required to regulate the in vivo motility of class II myosins, acetylated Tm had no effect on the motility of class I and V myosins. These findings illustrate a novel Tm-acetylation-state-dependent mechanism for regulating specific actomyosin cytoskeletal interactions." @default.
- W2122265029 created "2016-06-24" @default.
- W2122265029 creator A5024590878 @default.
- W2122265029 creator A5036239044 @default.
- W2122265029 creator A5050322482 @default.
- W2122265029 creator A5079261621 @default.
- W2122265029 creator A5079978509 @default.
- W2122265029 date "2010-10-01" @default.
- W2122265029 modified "2023-10-18" @default.
- W2122265029 title "The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast" @default.
- W2122265029 cites W14251027 @default.
- W2122265029 cites W1481760785 @default.
- W2122265029 cites W1518124859 @default.
- W2122265029 cites W1521831608 @default.
- W2122265029 cites W1523872131 @default.
- W2122265029 cites W1595495768 @default.
- W2122265029 cites W1954954760 @default.
- W2122265029 cites W1963533185 @default.
- W2122265029 cites W1966477752 @default.
- W2122265029 cites W1967716439 @default.
- W2122265029 cites W1971579210 @default.
- W2122265029 cites W1975302750 @default.
- W2122265029 cites W1975335205 @default.
- W2122265029 cites W1979609107 @default.
- W2122265029 cites W1990265320 @default.
- W2122265029 cites W1992924616 @default.
- W2122265029 cites W1995035844 @default.
- W2122265029 cites W2004900153 @default.
- W2122265029 cites W2014276510 @default.
- W2122265029 cites W2018480878 @default.
- W2122265029 cites W2036979978 @default.
- W2122265029 cites W2038253226 @default.
- W2122265029 cites W2040937769 @default.
- W2122265029 cites W2042228106 @default.
- W2122265029 cites W2049492301 @default.
- W2122265029 cites W2051257219 @default.
- W2122265029 cites W2052009851 @default.
- W2122265029 cites W2053590666 @default.
- W2122265029 cites W2059183452 @default.
- W2122265029 cites W2061365077 @default.
- W2122265029 cites W2064935758 @default.
- W2122265029 cites W2076120192 @default.
- W2122265029 cites W2080046860 @default.
- W2122265029 cites W2085308794 @default.
- W2122265029 cites W2094269474 @default.
- W2122265029 cites W2103118878 @default.
- W2122265029 cites W2111750583 @default.
- W2122265029 cites W2115930136 @default.
- W2122265029 cites W2123685989 @default.
- W2122265029 cites W2123789526 @default.
- W2122265029 cites W2136955958 @default.
- W2122265029 cites W2137213699 @default.
- W2122265029 cites W2138618719 @default.
- W2122265029 cites W2138865381 @default.
- W2122265029 cites W2141665440 @default.
- W2122265029 cites W2156523078 @default.
- W2122265029 cites W2161473412 @default.
- W2122265029 cites W2164590764 @default.
- W2122265029 cites W2164986499 @default.
- W2122265029 cites W2165579128 @default.
- W2122265029 cites W2194986544 @default.
- W2122265029 cites W2311110868 @default.
- W2122265029 doi "https://doi.org/10.1242/jcs.069971" @default.
- W2122265029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2939800" @default.
- W2122265029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20807799" @default.
- W2122265029 hasPublicationYear "2010" @default.
- W2122265029 type Work @default.
- W2122265029 sameAs 2122265029 @default.
- W2122265029 citedByCount "83" @default.
- W2122265029 countsByYear W21222650292012 @default.
- W2122265029 countsByYear W21222650292013 @default.
- W2122265029 countsByYear W21222650292014 @default.
- W2122265029 countsByYear W21222650292015 @default.
- W2122265029 countsByYear W21222650292016 @default.
- W2122265029 countsByYear W21222650292017 @default.
- W2122265029 countsByYear W21222650292018 @default.
- W2122265029 countsByYear W21222650292019 @default.
- W2122265029 countsByYear W21222650292020 @default.
- W2122265029 countsByYear W21222650292021 @default.
- W2122265029 countsByYear W21222650292022 @default.
- W2122265029 countsByYear W21222650292023 @default.
- W2122265029 crossrefType "journal-article" @default.
- W2122265029 hasAuthorship W2122265029A5024590878 @default.
- W2122265029 hasAuthorship W2122265029A5036239044 @default.
- W2122265029 hasAuthorship W2122265029A5050322482 @default.
- W2122265029 hasAuthorship W2122265029A5079261621 @default.
- W2122265029 hasAuthorship W2122265029A5079978509 @default.
- W2122265029 hasBestOaLocation W21222650291 @default.
- W2122265029 hasConcept C104317684 @default.
- W2122265029 hasConcept C119157956 @default.
- W2122265029 hasConcept C12554922 @default.
- W2122265029 hasConcept C125705527 @default.
- W2122265029 hasConcept C130861313 @default.
- W2122265029 hasConcept C14228908 @default.
- W2122265029 hasConcept C142669718 @default.
- W2122265029 hasConcept C1491633281 @default.
- W2122265029 hasConcept C205875245 @default.
- W2122265029 hasConcept C2779222958 @default.