Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122306770> ?p ?o ?g. }
- W2122306770 endingPage "3526" @default.
- W2122306770 startingPage "3518" @default.
- W2122306770 abstract "The Drosophila melanogaster flightless I gene is required for normal cellularization of the syncytial blastoderm. Highly conserved homologues of flightless I are present in Caenorhabditis elegans, mouse, and human. We have disrupted the mouse homologue Fliih by homologous recombination in embryonic stem cells. Heterozygous Fliih mutant mice develop normally, although the level of Fliih protein is reduced. Cultured homozygous Fliih mutant blastocysts hatch, attach, and form an outgrowing trophoblast cell layer, but egg cylinder formation fails and the embryos degenerate. Similarly, Fliih mutant embryos initiate implantation in vivo but then rapidly degenerate. We have constructed a transgenic mouse carrying the complete human FLII gene and shown that the FLII transgene is capable of rescuing the embryonic lethality of the homozygous targeted Fliih mutation. These results confirm the specific inactivation of the Fliih gene and establish that the human FLII gene and its gene product are functional in the mouse. The Fliih mouse mutant phenotype is much more severe than in the case of the related gelsolin family members gelsolin, villin, and CapG, where the homozygous mutant mice are viable and fertile but display alterations in cytoskeletal actin regulation." @default.
- W2122306770 created "2016-06-24" @default.
- W2122306770 creator A5000612576 @default.
- W2122306770 creator A5001721097 @default.
- W2122306770 creator A5020537976 @default.
- W2122306770 creator A5028415242 @default.
- W2122306770 creator A5031612228 @default.
- W2122306770 creator A5031787918 @default.
- W2122306770 creator A5035500527 @default.
- W2122306770 creator A5047545524 @default.
- W2122306770 creator A5062824841 @default.
- W2122306770 creator A5070261284 @default.
- W2122306770 creator A5075573766 @default.
- W2122306770 creator A5076272435 @default.
- W2122306770 creator A5085364867 @default.
- W2122306770 date "2002-05-01" @default.
- W2122306770 modified "2023-10-18" @default.
- W2122306770 title "Fliih, a Gelsolin-Related Cytoskeletal Regulator Essential for Early Mammalian Embryonic Development" @default.
- W2122306770 cites W1499460529 @default.
- W2122306770 cites W1872206109 @default.
- W2122306770 cites W1898299209 @default.
- W2122306770 cites W1925705209 @default.
- W2122306770 cites W1926287324 @default.
- W2122306770 cites W1971994001 @default.
- W2122306770 cites W1975945284 @default.
- W2122306770 cites W1979517563 @default.
- W2122306770 cites W1982021133 @default.
- W2122306770 cites W1983237714 @default.
- W2122306770 cites W1983430515 @default.
- W2122306770 cites W1985129504 @default.
- W2122306770 cites W1986703217 @default.
- W2122306770 cites W1990995529 @default.
- W2122306770 cites W1993834457 @default.
- W2122306770 cites W1994849711 @default.
- W2122306770 cites W2015222390 @default.
- W2122306770 cites W2016169728 @default.
- W2122306770 cites W2019572414 @default.
- W2122306770 cites W2020023483 @default.
- W2122306770 cites W2025994996 @default.
- W2122306770 cites W2027113655 @default.
- W2122306770 cites W2036692173 @default.
- W2122306770 cites W2039892043 @default.
- W2122306770 cites W2043027238 @default.
- W2122306770 cites W2045246692 @default.
- W2122306770 cites W2046857767 @default.
- W2122306770 cites W2058009854 @default.
- W2122306770 cites W2069249437 @default.
- W2122306770 cites W2084553204 @default.
- W2122306770 cites W2085465310 @default.
- W2122306770 cites W2086607694 @default.
- W2122306770 cites W2089695334 @default.
- W2122306770 cites W2096136044 @default.
- W2122306770 cites W2104830150 @default.
- W2122306770 cites W2107140960 @default.
- W2122306770 cites W2112119092 @default.
- W2122306770 cites W2126540114 @default.
- W2122306770 cites W2129959101 @default.
- W2122306770 cites W2156700030 @default.
- W2122306770 cites W2158284529 @default.
- W2122306770 cites W2169595927 @default.
- W2122306770 cites W2181429993 @default.
- W2122306770 cites W2202569420 @default.
- W2122306770 doi "https://doi.org/10.1128/mcb.22.10.3518-3526.2002" @default.
- W2122306770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133791" @default.
- W2122306770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11971982" @default.
- W2122306770 hasPublicationYear "2002" @default.
- W2122306770 type Work @default.
- W2122306770 sameAs 2122306770 @default.
- W2122306770 citedByCount "83" @default.
- W2122306770 countsByYear W21223067702012 @default.
- W2122306770 countsByYear W21223067702013 @default.
- W2122306770 countsByYear W21223067702014 @default.
- W2122306770 countsByYear W21223067702015 @default.
- W2122306770 countsByYear W21223067702016 @default.
- W2122306770 countsByYear W21223067702017 @default.
- W2122306770 countsByYear W21223067702018 @default.
- W2122306770 countsByYear W21223067702019 @default.
- W2122306770 countsByYear W21223067702020 @default.
- W2122306770 countsByYear W21223067702021 @default.
- W2122306770 countsByYear W21223067702022 @default.
- W2122306770 countsByYear W21223067702023 @default.
- W2122306770 crossrefType "journal-article" @default.
- W2122306770 hasAuthorship W2122306770A5000612576 @default.
- W2122306770 hasAuthorship W2122306770A5001721097 @default.
- W2122306770 hasAuthorship W2122306770A5020537976 @default.
- W2122306770 hasAuthorship W2122306770A5028415242 @default.
- W2122306770 hasAuthorship W2122306770A5031612228 @default.
- W2122306770 hasAuthorship W2122306770A5031787918 @default.
- W2122306770 hasAuthorship W2122306770A5035500527 @default.
- W2122306770 hasAuthorship W2122306770A5047545524 @default.
- W2122306770 hasAuthorship W2122306770A5062824841 @default.
- W2122306770 hasAuthorship W2122306770A5070261284 @default.
- W2122306770 hasAuthorship W2122306770A5075573766 @default.
- W2122306770 hasAuthorship W2122306770A5076272435 @default.
- W2122306770 hasAuthorship W2122306770A5085364867 @default.
- W2122306770 hasBestOaLocation W21223067701 @default.
- W2122306770 hasConcept C102230213 @default.
- W2122306770 hasConcept C104317684 @default.