Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122316595> ?p ?o ?g. }
- W2122316595 endingPage "1970" @default.
- W2122316595 startingPage "1960" @default.
- W2122316595 abstract "Helix kinks are a common feature of α-helical membrane proteins, but are thought to be rare in soluble proteins. In this study we find that kinks are a feature of long α-helices in both soluble and membrane proteins, rather than just transmembrane α-helices. The apparent rarity of kinks in soluble proteins is due to the relative infrequency of long helices (≥20 residues) in these proteins. We compare length-matched sets of soluble and membrane helices, and find that the frequency of kinks, the role of Proline, the patterns of other amino acid around kinks (allowing for the expected differences in amino acid distributions between the two types of protein), and the effects of hydrogen bonds are the same for the two types of helices. In both types of protein, helices that contain Proline in the second and subsequent turns are very frequently kinked. However, there are a sizeable proportion of kinked helices that do not contain a Proline in either their sequence or sequence homolog. Moreover, we observe that in soluble proteins, kinked helices have a structural preference in that they typically point into the solvent. Proteins 2014; 82:1960–1970. © 2014 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc." @default.
- W2122316595 created "2016-06-24" @default.
- W2122316595 creator A5015572211 @default.
- W2122316595 creator A5021165510 @default.
- W2122316595 creator A5078567532 @default.
- W2122316595 date "2014-04-16" @default.
- W2122316595 modified "2023-10-12" @default.
- W2122316595 title "Helix kinks are equally prevalent in soluble and membrane proteins" @default.
- W2122316595 cites W1973111841 @default.
- W2122316595 cites W1977610923 @default.
- W2122316595 cites W1990515637 @default.
- W2122316595 cites W1996083272 @default.
- W2122316595 cites W2004228538 @default.
- W2122316595 cites W2007415752 @default.
- W2122316595 cites W2007562782 @default.
- W2122316595 cites W2008708467 @default.
- W2122316595 cites W2012670872 @default.
- W2122316595 cites W2018182596 @default.
- W2122316595 cites W2018231450 @default.
- W2122316595 cites W2024211926 @default.
- W2122316595 cites W2024881833 @default.
- W2122316595 cites W2029023321 @default.
- W2122316595 cites W2030947664 @default.
- W2122316595 cites W2031282085 @default.
- W2122316595 cites W2033200533 @default.
- W2122316595 cites W2043017451 @default.
- W2122316595 cites W2046229791 @default.
- W2122316595 cites W2052717398 @default.
- W2122316595 cites W2062016903 @default.
- W2122316595 cites W2066562848 @default.
- W2122316595 cites W2068816427 @default.
- W2122316595 cites W2074266029 @default.
- W2122316595 cites W2074986801 @default.
- W2122316595 cites W2086415744 @default.
- W2122316595 cites W2090008239 @default.
- W2122316595 cites W2090022310 @default.
- W2122316595 cites W2092508662 @default.
- W2122316595 cites W2097775366 @default.
- W2122316595 cites W2100729071 @default.
- W2122316595 cites W2105537627 @default.
- W2122316595 cites W2106056376 @default.
- W2122316595 cites W2107777874 @default.
- W2122316595 cites W2109872885 @default.
- W2122316595 cites W2119168667 @default.
- W2122316595 cites W2127268158 @default.
- W2122316595 cites W2127395373 @default.
- W2122316595 cites W2129838159 @default.
- W2122316595 cites W2142209403 @default.
- W2122316595 cites W2143015200 @default.
- W2122316595 cites W2146074801 @default.
- W2122316595 cites W2153153865 @default.
- W2122316595 cites W2155147384 @default.
- W2122316595 cites W2157653619 @default.
- W2122316595 cites W2158714788 @default.
- W2122316595 cites W2160378127 @default.
- W2122316595 cites W2162050058 @default.
- W2122316595 cites W4212920271 @default.
- W2122316595 cites W2061026216 @default.
- W2122316595 doi "https://doi.org/10.1002/prot.24550" @default.
- W2122316595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4285789" @default.
- W2122316595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24638929" @default.
- W2122316595 hasPublicationYear "2014" @default.
- W2122316595 type Work @default.
- W2122316595 sameAs 2122316595 @default.
- W2122316595 citedByCount "62" @default.
- W2122316595 countsByYear W21223165952014 @default.
- W2122316595 countsByYear W21223165952015 @default.
- W2122316595 countsByYear W21223165952016 @default.
- W2122316595 countsByYear W21223165952017 @default.
- W2122316595 countsByYear W21223165952018 @default.
- W2122316595 countsByYear W21223165952019 @default.
- W2122316595 countsByYear W21223165952020 @default.
- W2122316595 countsByYear W21223165952021 @default.
- W2122316595 countsByYear W21223165952022 @default.
- W2122316595 countsByYear W21223165952023 @default.
- W2122316595 crossrefType "journal-article" @default.
- W2122316595 hasAuthorship W2122316595A5015572211 @default.
- W2122316595 hasAuthorship W2122316595A5021165510 @default.
- W2122316595 hasAuthorship W2122316595A5078567532 @default.
- W2122316595 hasBestOaLocation W21223165951 @default.
- W2122316595 hasConcept C104317684 @default.
- W2122316595 hasConcept C118892022 @default.
- W2122316595 hasConcept C12554922 @default.
- W2122316595 hasConcept C144647389 @default.
- W2122316595 hasConcept C155181932 @default.
- W2122316595 hasConcept C167625842 @default.
- W2122316595 hasConcept C170493617 @default.
- W2122316595 hasConcept C185592680 @default.
- W2122316595 hasConcept C18903297 @default.
- W2122316595 hasConcept C24530287 @default.
- W2122316595 hasConcept C2778112365 @default.
- W2122316595 hasConcept C2778530040 @default.
- W2122316595 hasConcept C2779281246 @default.
- W2122316595 hasConcept C2779815552 @default.
- W2122316595 hasConcept C2779965526 @default.
- W2122316595 hasConcept C41625074 @default.
- W2122316595 hasConcept C47701112 @default.
- W2122316595 hasConcept C515207424 @default.