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- W2122318304 abstract "Raynaud's phenomenon (RP) results from an exaggerated cutaneous vasospastic response to cold or emotional stress. The mechanisms that lead to impaired cutaneous vascular tone are complex. The regulation of cutaneous vasoconstriction and vasodilation, involves altered sympathetic nerve activity and a host of neuronal regulators, including adrenergic and non-adrenergic, as well as REDOX signalling and other signalling such as the RhoA/ROCK pathway. This review summarises the literature concerning the regulation of vascular tone by neurohumoral factors that may be involved in RP and systemic sclerosis (SSc)." @default.
- W2122318304 created "2016-06-24" @default.
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- W2122318304 date "2009-01-01" @default.
- W2122318304 modified "2023-10-13" @default.
- W2122318304 title "Neuronal Regulators and Vascular Dysfunction in Raynauds Phenomenon and Systemic Sclerosis" @default.
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- W2122318304 doi "https://doi.org/10.2174/157016109787354105" @default.
- W2122318304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19149638" @default.
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