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- W2122330625 abstract "Several mucoid strains and one nonmucoid strain of Pseudomonas aeruginosawere grown in subinhibitory concentrations of various aminoglycosides, β-lactams, and ciprofloxacin. At antibiotic concentrations that did not affect bacterial growth, aminoglycosides inhibited the excretion of alginate capsule and the production of the iron-chelating siderophores. The same concentrations also disturbed other aspects of the bacterium's iron metabolism, manifested by reduced cellular levels of cytochromes and catalase. β-lactams, except for cefotaxime, and ciprofloxacin did not reduce alginate excretion. These effects on virulence factors are likely to contribute to the efficacy of aminoglycosides." @default.
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- W2122330625 date "1988-06-01" @default.
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- W2122330625 title "NOVEL MODES OF ACTION OF AMINOGLYCOSIDE ANTIBIOTICS AGAINST PSEUDOMONAS AERUGINOSA" @default.
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- W2122330625 doi "https://doi.org/10.1016/s0140-6736(88)92179-4" @default.
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