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• W2122332446 abstract "The energetics of protein-DNA interactions are often modeled using so-called statistical potentials, that is, energy models derived from the atomic structures of protein-DNA complexes. Many statistical protein-DNA potentials based on differing theoretical assumptions have been investigated, but little attention has been paid to the types of data and the parameter estimation process used in deriving the statistical potentials. We describe three enhancements to statistical potential inference that significantly improve the accuracy of predicted protein-DNA interactions: (i) incorporation of binding energy data of protein-DNA complexes, in conjunction with their X-ray crystal structures, (ii) use of spatially-aware parameter fitting, and (iii) use of ensemble-based parameter fitting. We apply these enhancements to three widely-used statistical potentials and use the resulting enhanced potentials in a structure-based prediction of the DNA binding sites of proteins. These enhancements are directly applicable to all statistical potentials used in protein-DNA modeling, and we show that they can improve the accuracy of predicted DNA binding sites by up to 21%." @default.
• W2122332446 created "2016-06-24" @default.
• W2122332446 creator A5002987125 @default.
• W2122332446 creator A5073244319 @default.
• W2122332446 date "2012-11-12" @default.
• W2122332446 modified "2023-09-26" @default.
• W2122332446 title "Three enhancements to the inference of statistical protein-DNA potentials" @default.
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• W2122332446 cites W1971170993 @default.
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• W2122332446 cites W1980825481 @default.
• W2122332446 cites W198431410 @default.
• W2122332446 cites W2003897898 @default.
• W2122332446 cites W2007688939 @default.
• W2122332446 cites W2007970461 @default.
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• W2122332446 cites W2031587474 @default.
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• W2122332446 cites W2036374281 @default.
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• W2122332446 cites W2094604037 @default.
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• W2122332446 doi "https://doi.org/10.1002/prot.24201" @default.
• W2122332446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4104999" @default.
• W2122332446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23042633" @default.
• W2122332446 hasPublicationYear "2012" @default.
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