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- W2122342005 abstract "Abstract Motivation: Time series expression experiments are an increasingly popular method for studying a wide range of biological systems. Here we developed an algorithm that can infer the local network of gene–gene interactions surrounding a gene of interest. This is achieved by a perturbation of the gene of interest and subsequently measuring the gene expression profiles at multiple time points. We applied this algorithm to computer simulated data and to experimental data on a nine gene network in Escherichia coli. Results: In this paper we show that it is possible to recover the gene regulatory network from a time series data of gene expression following a perturbation to the cell. We show this both on simulated data and on a nine gene subnetwork part of the DNA-damage response pathway (SOS pathway) in the bacteria E. coli. Contact: dibernardo@tigem.it Supplementary information: Supplementary data are available at" @default.
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- W2122342005 date "2006-01-17" @default.
- W2122342005 modified "2023-10-06" @default.
- W2122342005 title "Inference of gene regulatory networks and compound mode of action from time course gene expression profiles" @default.
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- W2122342005 doi "https://doi.org/10.1093/bioinformatics/btl003" @default.
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