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• W2122342236 abstract "Gensenosides, the active ingredients of Chinese herbal medicine Panax ginseng, have a wide spectrum of medical effects, such as anti-tumorigenic, angiosuppressive, adaptogenic, and anti-fatigue activities. In the present study, we have investigated the neuroprotective effect of 20(R)-ginsenoside Rg3 (20(R)-Rg3) against transient focal cerebral ischemia in male Sprague-Dawley (SD) rats. The middle cerebral artery was occluded for 2 h in rats and then reperfused for 24 h. The behavioral disturbance was evaluated according to neurological deficit scores, and the infarct volumes were evaluated by 2,3,5-triphenyltetrazolium chloride (TTC) staining; in addition, ischemia-mediated apoptosis was examined using the method of terminal deoxynucleotidyl transferase (TdT)-mediated d-UTP nick end labeling (TUNEL). The expressions of calpain I and caspase-3 mRNA in hippocampal CA1 region were further assayed using in situ hybridization, in order to clarify the neuroprotective mechanism of 20(R)-Rg3. 20(R)-Rg3 at the doses of 10 and 20 mg kg−1 i.p., but not 5 mg kg−1, showed significant neuroprotective effect in rats against focal cerebral ischemic injury by markedly reducing cerebral infarct volumes and degrading infarct rate of TTC-stained coronal brain sections, and improving behavior of the animals. Our results also suggested that 20(R)-Rg3 (10 and 20 mg kg−1) could significantly suppress the expressions of calpain I and caspase-3 mRNA. These results indicated that 20(R)-Rg3 attenuates the neuronal apoptosis caused by cerebral ischemia–reperfusion injury and its neuprotective effect may be involved in the downregulation of calpain I and caspase-3." @default.
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• W2122342236 date "2012-09-01" @default.
• W2122342236 modified "2023-09-25" @default.
• W2122342236 title "Neuroprotective effect of 20(R)-ginsenoside Rg3 against transient focal cerebral ischemia in rats" @default.
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• W2122342236 doi "https://doi.org/10.1016/j.neulet.2012.08.022" @default.
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