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- W2122352218 abstract "The eukaryotic nucleolus is multifunctional and involved in the metabolism and assembly of many different RNAs and ribonucleoprotein particles as well as in cellular functions, such as cell division and transcriptional silencing in plants. We previously showed that Arabidopsis thaliana exon junction complex proteins associate with the nucleolus, suggesting a role for the nucleolus in mRNA production. Here, we report that the plant nucleolus contains mRNAs, including fully spliced, aberrantly spliced, and single exon gene transcripts. Aberrant mRNAs are much more abundant in nucleolar fractions, while fully spliced products are more abundant in nucleoplasmic fractions. The majority of the aberrant transcripts contain premature termination codons and have characteristics of nonsense-mediated decay (NMD) substrates. A direct link between NMD and the nucleolus is shown by increased levels of the same aberrant transcripts in both the nucleolus and in Up-frameshift (upf) mutants impaired in NMD. In addition, the NMD factors UPF3 and UPF2 localize to the nucleolus, suggesting that the Arabidopsis nucleolus is therefore involved in identifying aberrant mRNAs and NMD." @default.
- W2122352218 created "2016-06-24" @default.
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- W2122352218 creator A5078275181 @default.
- W2122352218 date "2009-07-01" @default.
- W2122352218 modified "2023-10-01" @default.
- W2122352218 title "Aberrant mRNA Transcripts and the Nonsense-Mediated Decay Proteins UPF2 and UPF3 Are Enriched in the<i>Arabidopsis</i>Nucleolus " @default.
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- W2122352218 doi "https://doi.org/10.1105/tpc.109.067736" @default.
- W2122352218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2729600" @default.
- W2122352218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19602621" @default.
- W2122352218 hasPublicationYear "2009" @default.
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