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• W2122362671 abstract "The ammonium permease Mep2 is required for the induction of pseudohyphal growth, a process in Saccharomyces cerevisiae that occurs in response to nutrient limitation. Mep2 has both a transport and a regulatory function, supporting models in which Mep2 acts as a sensor of ammonium availability. Potentially similar ammonium permease-dependent regulatory cascades operate in other fungi, and they may also function in animals via the homologous Rh proteins; however, little is known about the molecular mechanisms that mediate ammonium sensing. We show that Mep2 is localized to the cell surface during pseudohyphal growth, and it is required for both filamentous and invasive growth. Analysis of site-directed Mep2 mutants in residues lining the ammonia-conducting channel reveal separation of function alleles (transport and signaling defective; transport-proficient/signaling defective), indicating transport is necessary but not sufficient to sense ammonia. Furthermore, Mep2 overexpression enhances differentiation under normally repressive conditions and induces a transcriptional profile that is consistent with activation of the mitogen-activated protein (MAP) kinase pathway. This finding is supported by epistasis analysis establishing that the known role of the MAP kinase pathway in pseudohyphal growth is linked to Mep2 function. Together, these data strengthen the model that Mep2-like proteins are nutrient sensing transceptors that govern cellular differentiation." @default.
• W2122362671 created "2016-06-24" @default.
• W2122362671 creator A5037932444 @default.
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• W2122362671 creator A5071220212 @default.
• W2122362671 creator A5071531544 @default.
• W2122362671 creator A5085587138 @default.
• W2122362671 date "2008-07-01" @default.
• W2122362671 modified "2023-10-18" @default.
• W2122362671 title "A Mep2-dependent Transcriptional Profile Links Permease Function to Gene Expression during Pseudohyphal Growth in<i>Saccharomyces cerevisiae</i>" @default.
• W2122362671 cites W1508614407 @default.
• W2122362671 cites W1806557221 @default.
• W2122362671 cites W1831514952 @default.
• W2122362671 cites W1857076467 @default.
• W2122362671 cites W1910257284 @default.
• W2122362671 cites W1940079479 @default.
• W2122362671 cites W1946207508 @default.
• W2122362671 cites W1973164214 @default.
• W2122362671 cites W1977625601 @default.
• W2122362671 cites W1985001103 @default.
• W2122362671 cites W1986010823 @default.
• W2122362671 cites W1993389187 @default.
• W2122362671 cites W1994360367 @default.
• W2122362671 cites W1994780794 @default.
• W2122362671 cites W1995087505 @default.
• W2122362671 cites W2004089557 @default.
• W2122362671 cites W2005188492 @default.
• W2122362671 cites W2007391251 @default.
• W2122362671 cites W2014176614 @default.
• W2122362671 cites W2020749481 @default.
• W2122362671 cites W2037036397 @default.
• W2122362671 cites W2037338352 @default.
• W2122362671 cites W2038191669 @default.
• W2122362671 cites W2041500621 @default.
• W2122362671 cites W2047207683 @default.
• W2122362671 cites W2050721857 @default.
• W2122362671 cites W2053304217 @default.
• W2122362671 cites W2055624868 @default.
• W2122362671 cites W2055952803 @default.
• W2122362671 cites W2059464705 @default.
• W2122362671 cites W2059775037 @default.
• W2122362671 cites W2060742513 @default.
• W2122362671 cites W2062249432 @default.
• W2122362671 cites W2062867942 @default.
• W2122362671 cites W2064352971 @default.
• W2122362671 cites W2068413127 @default.
• W2122362671 cites W2071468845 @default.
• W2122362671 cites W2074204387 @default.
• W2122362671 cites W2075586010 @default.
• W2122362671 cites W2083735592 @default.
• W2122362671 cites W2086285521 @default.
• W2122362671 cites W2092251618 @default.
• W2122362671 cites W2093434319 @default.
• W2122362671 cites W2098337864 @default.
• W2122362671 cites W2102406695 @default.
• W2122362671 cites W2106450047 @default.
• W2122362671 cites W2110247397 @default.
• W2122362671 cites W2113731096 @default.
• W2122362671 cites W2116289234 @default.
• W2122362671 cites W2117403595 @default.
• W2122362671 cites W2118099055 @default.
• W2122362671 cites W2118600791 @default.
• W2122362671 cites W2121103116 @default.
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• W2122362671 cites W2127270784 @default.
• W2122362671 cites W2131043780 @default.
• W2122362671 cites W2132859280 @default.
• W2122362671 cites W2137284085 @default.
• W2122362671 cites W2137990078 @default.
• W2122362671 cites W2139947030 @default.
• W2122362671 cites W2144833268 @default.
• W2122362671 cites W2145053175 @default.
• W2122362671 cites W2148684376 @default.
• W2122362671 cites W2152745547 @default.
• W2122362671 cites W2153201376 @default.
• W2122362671 cites W2156500567 @default.
• W2122362671 cites W2161817279 @default.
• W2122362671 cites W2168421316 @default.
• W2122362671 cites W2169805130 @default.
• W2122362671 cites W2170633329 @default.
• W2122362671 cites W2171692650 @default.
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• W2122362671 doi "https://doi.org/10.1091/mbc.e08-01-0033" @default.
• W2122362671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2441671" @default.
• W2122362671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18434596" @default.
• W2122362671 hasPublicationYear "2008" @default.
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