Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122364231> ?p ?o ?g. }
- W2122364231 abstract "Cell-to-cell variability in gene expression is important for many processes in biology, including embryonic development and stem cell homeostasis. While heterogeneity of gene expression levels has been extensively studied, less attention has been paid to mRNA polyadenylation isoform choice. 3' untranslated regions regulate mRNA fate, and their choice is tightly controlled during development, but how 3' isoform usage varies within genetically and developmentally homogeneous cell populations has not been explored. Here, we perform genome-wide quantification of polyadenylation site usage in single mouse embryonic and neural stem cells using a novel single-cell transcriptomic method, BATSeq. By applying BATBayes, a statistical framework for analyzing single-cell isoform data, we find that while the developmental state of the cell globally determines isoform usage, single cells from the same state differ in the choice of isoforms. Notably this variation exceeds random selection with equal preference in all cells, a finding that was confirmed by RNA FISH data. Variability in 3' isoform choice has potential implications on functional cell-to-cell heterogeneity as well as utility in resolving cell populations." @default.
- W2122364231 created "2016-06-24" @default.
- W2122364231 creator A5002497731 @default.
- W2122364231 creator A5010457547 @default.
- W2122364231 creator A5022280742 @default.
- W2122364231 creator A5023990259 @default.
- W2122364231 creator A5029601108 @default.
- W2122364231 creator A5056450824 @default.
- W2122364231 creator A5063260938 @default.
- W2122364231 date "2015-06-01" @default.
- W2122364231 modified "2023-10-14" @default.
- W2122364231 title "Single‐cell polyadenylation site mapping reveals 3′ isoform choice variability" @default.
- W2122364231 cites W1652680663 @default.
- W2122364231 cites W1964727443 @default.
- W2122364231 cites W1966758700 @default.
- W2122364231 cites W1978355305 @default.
- W2122364231 cites W1981641790 @default.
- W2122364231 cites W1984397453 @default.
- W2122364231 cites W1984412074 @default.
- W2122364231 cites W2001432314 @default.
- W2122364231 cites W2005361347 @default.
- W2122364231 cites W2008934800 @default.
- W2122364231 cites W2009743304 @default.
- W2122364231 cites W2013324041 @default.
- W2122364231 cites W2025828346 @default.
- W2122364231 cites W2028845751 @default.
- W2122364231 cites W2033152634 @default.
- W2122364231 cites W2035047647 @default.
- W2122364231 cites W2040889971 @default.
- W2122364231 cites W2045317504 @default.
- W2122364231 cites W2057765075 @default.
- W2122364231 cites W2062118486 @default.
- W2122364231 cites W2063151549 @default.
- W2122364231 cites W2068881679 @default.
- W2122364231 cites W2071010503 @default.
- W2122364231 cites W2072066100 @default.
- W2122364231 cites W2072806829 @default.
- W2122364231 cites W2073461718 @default.
- W2122364231 cites W2083699794 @default.
- W2122364231 cites W2084942072 @default.
- W2122364231 cites W2087789109 @default.
- W2122364231 cites W2096441981 @default.
- W2122364231 cites W2098980484 @default.
- W2122364231 cites W2099578065 @default.
- W2122364231 cites W2099915768 @default.
- W2122364231 cites W2103134419 @default.
- W2122364231 cites W2108264419 @default.
- W2122364231 cites W2110768394 @default.
- W2122364231 cites W2111510713 @default.
- W2122364231 cites W2114870653 @default.
- W2122364231 cites W2115368299 @default.
- W2122364231 cites W2117945751 @default.
- W2122364231 cites W2118834857 @default.
- W2122364231 cites W2121690903 @default.
- W2122364231 cites W2122438081 @default.
- W2122364231 cites W2128227827 @default.
- W2122364231 cites W2129375080 @default.
- W2122364231 cites W2134526812 @default.
- W2122364231 cites W2137065828 @default.
- W2122364231 cites W2140258573 @default.
- W2122364231 cites W2141688036 @default.
- W2122364231 cites W2146994105 @default.
- W2122364231 cites W2149573463 @default.
- W2122364231 cites W2153661237 @default.
- W2122364231 cites W2157727502 @default.
- W2122364231 cites W2164440878 @default.
- W2122364231 cites W2171280873 @default.
- W2122364231 cites W2171327609 @default.
- W2122364231 cites W2171501288 @default.
- W2122364231 cites W2400063122 @default.
- W2122364231 cites W4230096730 @default.
- W2122364231 doi "https://doi.org/10.15252/msb.20156198" @default.
- W2122364231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4501847" @default.
- W2122364231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26040288" @default.
- W2122364231 hasPublicationYear "2015" @default.
- W2122364231 type Work @default.
- W2122364231 sameAs 2122364231 @default.
- W2122364231 citedByCount "54" @default.
- W2122364231 countsByYear W21223642312015 @default.
- W2122364231 countsByYear W21223642312016 @default.
- W2122364231 countsByYear W21223642312017 @default.
- W2122364231 countsByYear W21223642312018 @default.
- W2122364231 countsByYear W21223642312019 @default.
- W2122364231 countsByYear W21223642312020 @default.
- W2122364231 countsByYear W21223642312021 @default.
- W2122364231 countsByYear W21223642312022 @default.
- W2122364231 crossrefType "journal-article" @default.
- W2122364231 hasAuthorship W2122364231A5002497731 @default.
- W2122364231 hasAuthorship W2122364231A5010457547 @default.
- W2122364231 hasAuthorship W2122364231A5022280742 @default.
- W2122364231 hasAuthorship W2122364231A5023990259 @default.
- W2122364231 hasAuthorship W2122364231A5029601108 @default.
- W2122364231 hasAuthorship W2122364231A5056450824 @default.
- W2122364231 hasAuthorship W2122364231A5063260938 @default.
- W2122364231 hasBestOaLocation W21223642311 @default.
- W2122364231 hasConcept C104317684 @default.
- W2122364231 hasConcept C105580179 @default.
- W2122364231 hasConcept C142575336 @default.
- W2122364231 hasConcept C145103041 @default.
- W2122364231 hasConcept C148738053 @default.