FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122380098> ?p ?o ?g. }

• W2122380098 endingPage "1443" @default.
• W2122380098 startingPage "1435" @default.
• W2122380098 abstract "Background. Human immunodeficiency virus type 1 (HIV-1) uses the CD4 receptor and a coreceptor to gain cell entry. Coreceptor usage is mainly determined by the V3 loop of gp120. Therefore, coreceptor usage is currently inferred from the genotype on the basis of V3 alone. However, several mutations outside V3 have been repeatedly reported to influence coreceptor usage. In this study, the impact of the V2 loop on coreceptor usage prediction was analyzed. Methods. Sequences were analyzed for differences at specific positions and position-independent features with the Fisher exact and Student t tests. Prediction models were trained with support vector machines and evaluated in cross-validation on clonal data. Models trained on the clonal data set were validated on 2 clinical data sets. Results. Several mutations and position-independent features within V2 were statistically significantly different between R5 and X4 viruses. Cross-validation on the clonal data set revealed a statistically significantly higher area under the receiver operating characteristic curve if features of both loops were used, compared with those using only V2 or V3 alone. Similar results were found with clinically derived data sets. Conclusions. The ability of the V2 loop to improve coreceptor usage prediction has been shown in a large data set. Utilization of this information can lead to considerable improvements in the prediction of coreceptor use both on clonal data sets and on clinically derived data sets." @default.
• W2122380098 created "2016-06-24" @default.
• W2122380098 creator A5023556977 @default.
• W2122380098 creator A5036502017 @default.
• W2122380098 creator A5068026339 @default.
• W2122380098 creator A5074420045 @default.
• W2122380098 creator A5084837382 @default.
• W2122380098 creator A5085293293 @default.
• W2122380098 date "2010-11-01" @default.
• W2122380098 modified "2023-09-25" @default.
• W2122380098 title "Improved Prediction of HIV‐1 Coreceptor Usage with Sequence Information from the Second Hypervariable Loop of gp120" @default.
• W2122380098 cites W101727076 @default.
• W2122380098 cites W1492020089 @default.
• W2122380098 cites W1574862351 @default.
• W2122380098 cites W1604938182 @default.
• W2122380098 cites W1607005809 @default.
• W2122380098 cites W1782049572 @default.
• W2122380098 cites W1900729316 @default.
• W2122380098 cites W1918933327 @default.
• W2122380098 cites W1934064435 @default.
• W2122380098 cites W1938763205 @default.
• W2122380098 cites W1966261980 @default.
• W2122380098 cites W1968057545 @default.
• W2122380098 cites W1981440980 @default.
• W2122380098 cites W1981644527 @default.
• W2122380098 cites W1986574361 @default.
• W2122380098 cites W1987534893 @default.
• W2122380098 cites W1989035987 @default.
• W2122380098 cites W1996183144 @default.
• W2122380098 cites W1998674683 @default.
• W2122380098 cites W1999048558 @default.
• W2122380098 cites W2004444899 @default.
• W2122380098 cites W2005925428 @default.
• W2122380098 cites W2007021820 @default.
• W2122380098 cites W2009467617 @default.
• W2122380098 cites W2016264635 @default.
• W2122380098 cites W2018554207 @default.
• W2122380098 cites W2026444780 @default.
• W2122380098 cites W2027074843 @default.
• W2122380098 cites W2045949915 @default.
• W2122380098 cites W2066480278 @default.
• W2122380098 cites W2070988500 @default.
• W2122380098 cites W2090630729 @default.
• W2122380098 cites W2093558340 @default.
• W2122380098 cites W2104275641 @default.
• W2122380098 cites W2104317084 @default.
• W2122380098 cites W2106882534 @default.
• W2122380098 cites W2123311117 @default.
• W2122380098 cites W2127020454 @default.
• W2122380098 cites W2145126338 @default.
• W2122380098 cites W2147169218 @default.
• W2122380098 cites W2152026267 @default.
• W2122380098 cites W2160314813 @default.
• W2122380098 cites W2164501148 @default.
• W2122380098 cites W2169054534 @default.
• W2122380098 cites W2169561386 @default.
• W2122380098 cites W2172198911 @default.
• W2122380098 cites W2328176404 @default.
• W2122380098 cites W2333042482 @default.
• W2122380098 cites W2409714257 @default.
• W2122380098 cites W795105947 @default.
• W2122380098 doi "https://doi.org/10.1086/656600" @default.
• W2122380098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20874088" @default.
• W2122380098 hasPublicationYear "2010" @default.
• W2122380098 type Work @default.
• W2122380098 sameAs 2122380098 @default.
• W2122380098 citedByCount "34" @default.
• W2122380098 countsByYear W21223800982012 @default.
• W2122380098 countsByYear W21223800982013 @default.
• W2122380098 countsByYear W21223800982014 @default.
• W2122380098 countsByYear W21223800982015 @default.
• W2122380098 countsByYear W21223800982016 @default.
• W2122380098 countsByYear W21223800982017 @default.
• W2122380098 countsByYear W21223800982019 @default.
• W2122380098 countsByYear W21223800982020 @default.
• W2122380098 countsByYear W21223800982022 @default.
• W2122380098 crossrefType "journal-article" @default.
• W2122380098 hasAuthorship W2122380098A5023556977 @default.
• W2122380098 hasAuthorship W2122380098A5036502017 @default.
• W2122380098 hasAuthorship W2122380098A5068026339 @default.
• W2122380098 hasAuthorship W2122380098A5074420045 @default.
• W2122380098 hasAuthorship W2122380098A5084837382 @default.
• W2122380098 hasAuthorship W2122380098A5085293293 @default.
• W2122380098 hasBestOaLocation W21223800981 @default.
• W2122380098 hasConcept C10138342 @default.
• W2122380098 hasConcept C104317684 @default.
• W2122380098 hasConcept C114614502 @default.
• W2122380098 hasConcept C154945302 @default.
• W2122380098 hasConcept C159047783 @default.
• W2122380098 hasConcept C162324750 @default.
• W2122380098 hasConcept C167625842 @default.
• W2122380098 hasConcept C177264268 @default.
• W2122380098 hasConcept C184670325 @default.
• W2122380098 hasConcept C198082294 @default.
• W2122380098 hasConcept C199360897 @default.
• W2122380098 hasConcept C2779921545 @default.
• W2122380098 hasConcept C3013748606 @default.
• W2122380098 hasConcept C33923547 @default.

• next