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- W2122382992 abstract "Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation. Changes in ploidy can also result from pathophysiological events that are caused by viral-induced cell fusion or erroneous cell division. Tetraploidization can initiate chromosomal instability (CIN), probably owing to supernumerary centrosomes and the doubled chromosome mass. CIN, in turn, might persist or soon give way to a stably propagating but aneuploid karyotype. Both CIN and stable aneuploidy are commonly observed in cancers. Recently, it has been proposed that an increased number of chromosome sets can promote cell transformation and give rise to an aneuploid tumor. Here, we review how tetraploidy can occur and describe the cellular responses to increased ploidy. Furthermore, we discuss how the specific physiological changes that are triggered by polyploidization might be used as novel targets for cancer therapy." @default.
- W2122382992 created "2016-06-24" @default.
- W2122382992 creator A5002484670 @default.
- W2122382992 creator A5044856730 @default.
- W2122382992 date "2008-12-01" @default.
- W2122382992 modified "2023-10-18" @default.
- W2122382992 title "The consequences of tetraploidy and aneuploidy" @default.
- W2122382992 cites W1548202728 @default.
- W2122382992 cites W1867836395 @default.
- W2122382992 cites W1920350377 @default.
- W2122382992 cites W1963759286 @default.
- W2122382992 cites W1965505970 @default.
- W2122382992 cites W1968263047 @default.
- W2122382992 cites W1970442105 @default.
- W2122382992 cites W1970495849 @default.
- W2122382992 cites W1979685062 @default.
- W2122382992 cites W1981427365 @default.
- W2122382992 cites W1983461362 @default.
- W2122382992 cites W1984328656 @default.
- W2122382992 cites W1989193912 @default.
- W2122382992 cites W1991736202 @default.
- W2122382992 cites W1992181243 @default.
- W2122382992 cites W1995339978 @default.
- W2122382992 cites W1996152576 @default.
- W2122382992 cites W2000916118 @default.
- W2122382992 cites W2001258296 @default.
- W2122382992 cites W2002278342 @default.
- W2122382992 cites W2007474198 @default.
- W2122382992 cites W2010032067 @default.
- W2122382992 cites W2010749771 @default.
- W2122382992 cites W2012668509 @default.
- W2122382992 cites W2017050402 @default.
- W2122382992 cites W2020431095 @default.
- W2122382992 cites W2020650477 @default.
- W2122382992 cites W2021589500 @default.
- W2122382992 cites W2021684321 @default.
- W2122382992 cites W2025829112 @default.
- W2122382992 cites W2026754375 @default.
- W2122382992 cites W2030086669 @default.
- W2122382992 cites W2030202463 @default.
- W2122382992 cites W2034086671 @default.
- W2122382992 cites W2048938594 @default.
- W2122382992 cites W2051200214 @default.
- W2122382992 cites W2051897540 @default.
- W2122382992 cites W2055896653 @default.
- W2122382992 cites W2059809467 @default.
- W2122382992 cites W2062201772 @default.
- W2122382992 cites W2072895299 @default.
- W2122382992 cites W2073213328 @default.
- W2122382992 cites W2073868774 @default.
- W2122382992 cites W2075601868 @default.
- W2122382992 cites W2077685283 @default.
- W2122382992 cites W2080308138 @default.
- W2122382992 cites W2081201259 @default.
- W2122382992 cites W2083275000 @default.
- W2122382992 cites W2084139224 @default.
- W2122382992 cites W2087502608 @default.
- W2122382992 cites W2089087583 @default.
- W2122382992 cites W2089596886 @default.
- W2122382992 cites W2089685532 @default.
- W2122382992 cites W2089950231 @default.
- W2122382992 cites W2091327176 @default.
- W2122382992 cites W2095486134 @default.
- W2122382992 cites W2099268087 @default.
- W2122382992 cites W2101488899 @default.
- W2122382992 cites W2102922697 @default.
- W2122382992 cites W2107648723 @default.
- W2122382992 cites W2108172661 @default.
- W2122382992 cites W2115667307 @default.
- W2122382992 cites W2128126810 @default.
- W2122382992 cites W2134435289 @default.
- W2122382992 cites W2139682891 @default.
- W2122382992 cites W2139718226 @default.
- W2122382992 cites W2140846028 @default.
- W2122382992 cites W2141513637 @default.
- W2122382992 cites W2142583529 @default.
- W2122382992 cites W2145869314 @default.
- W2122382992 cites W2151108782 @default.
- W2122382992 cites W2154083988 @default.
- W2122382992 cites W2155380705 @default.
- W2122382992 cites W2156393663 @default.
- W2122382992 cites W2157747593 @default.
- W2122382992 cites W2157993533 @default.
- W2122382992 cites W2158160769 @default.
- W2122382992 cites W2160411950 @default.
- W2122382992 cites W2161354534 @default.
- W2122382992 cites W2162311389 @default.
- W2122382992 cites W2169640266 @default.
- W2122382992 cites W2170673162 @default.
- W2122382992 cites W4240237951 @default.
- W2122382992 doi "https://doi.org/10.1242/jcs.039537" @default.
- W2122382992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19020304" @default.
- W2122382992 hasPublicationYear "2008" @default.
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