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- W2122398177 abstract "The antimutagenic and antioxidant properties of various phenolic fractions obtained from Andean purple corn were examined by the Ames test and the DPPH antiradical assay. An anthocyanin-rich water fraction (WF) and an ethyl acetate fraction (EAF) showed a dose-dependent antimutagenic behavior against the food mutagen Trp-P-1 with IC50 values of 321.7 ± 21.36 and 95.2 ± 10.95 μg of chlorogenic acid equiv/plate, respectively, indicating that EAF was a more potent antimutagen. The antioxidant activities for WF and EAF were 1.019 ± 0.05 and 0.838 ± 0.11 μg of Trolox equiv/μg of phenolics, respectively. Further fractionation of WF and EAF revealed an ethyl acetate subfraction, EA-IV, with high antimutagen potency that contained a quercetin derivative. The mechanism of antimutagenic action of the WF is predominantly a blocking effect on the S-9 Mix activation system of the mutagen, whereas for the EAF, it is a dual mechanism involving blocking of the S-9 Mix and a scavenging action on Trp-P-1 electrophiles. Keywords: Purple corn extract; phenolic compounds; antimutagenic activity; antioxidant activity; mechanism of antimutagenic action" @default.
- W2122398177 created "2016-06-24" @default.
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- W2122398177 date "2006-06-01" @default.
- W2122398177 modified "2023-10-06" @default.
- W2122398177 title "Antimutagenic and Antioxidant Properties of Phenolic Fractions from Andean Purple Corn (<i>Zea mays</i> L.)" @default.
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- W2122398177 doi "https://doi.org/10.1021/jf0531050" @default.
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