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- W2122410080 endingPage "485" @default.
- W2122410080 startingPage "473" @default.
- W2122410080 abstract "Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a diverse group of compounds that inhibit HIV Type 1 reverse transcriptase. Although possessing a common mechanism of action, the approved NNRTIs, delavirdine, efavirenz and nevirapine, differ in structural and pharmacokinetic characteristics. Each of the NNRTIs undergoes biotransformation by the cytochrome P450 (CYP) enzyme system, thus making them prone to clinically significant drug interactions when combined with other antiretrovirals. In addition, they interact with other concurrent medications and complementary/alternative medicines, acting as either inducers or inhibitors of drug-metabolising CYP enzymes. These drug interactions become an important consideration in the clinical use of these agents when designing combination regimens, as recommended by current guidelines. This review provides an updated summary of pharmacokinetic interactions with NNRTIs." @default.
- W2122410080 created "2016-06-24" @default.
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- W2122410080 date "2005-09-29" @default.
- W2122410080 modified "2023-10-16" @default.
- W2122410080 title "Pharmacokinetic drug interactions with non-nucleoside reverse transcriptase inhibitors" @default.
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- W2122410080 doi "https://doi.org/10.1517/17425255.1.3.473" @default.
- W2122410080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16863456" @default.
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