FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122419529> ?p ?o ?g. }

• W2122419529 endingPage "3556" @default.
• W2122419529 startingPage "3546" @default.
• W2122419529 abstract "Abstract CXC chemokines and their cognate receptors have been implicated widely in cancer pathogenesis. In this study, we report a critical causal relationship between CXCR6 expression and tumorigenesis in the setting of human hepatocellular carcinoma (HCC). Among the CXC chemokine receptors, only CXCR6 was detected in all the hepatoma cell lines studied. Moreover, in HCC tissue, CXCR6 expression was significantly higher than in noncancerous liver tissues. Reduction of CXCR6 or its ligand CXCL16 in cancer cells reduced cell invasion in vitro and tumor growth, angiogenesis, and metastases in vivo. Importantly, loss of CXCR6 led to reduced Gr-1+ neutrophil infiltration and decreased neoangiogenesis in hepatoma xenografts via inhibition of proinflammatory cytokine production. Clinically, high expression of CXCR6 was an independent predictor of increased recurrence and poor survival in HCCs. Human HCC samples expressing high levels of CXCR6 also contained an increased number of CD66b+ neutrophils and microvessels, and the combination of CXCR6 and neutrophils was a superior predictor of recurrence and survival than either marker used alone. Together, our findings suggest that elevated expression of CXCR6 promotes HCC invasiveness and a protumor inflammatory environment and is associated with poor patient outcome. These results support the concept that inhibition of the CXCR6–CXCL16 pathway may improve prognosis after HCC treatment. Cancer Res; 72(14); 3546–56. ©2012 AACR." @default.
• W2122419529 created "2016-06-24" @default.
• W2122419529 creator A5002560091 @default.
• W2122419529 creator A5013799944 @default.
• W2122419529 creator A5015071376 @default.
• W2122419529 creator A5021073603 @default.
• W2122419529 creator A5029363724 @default.
• W2122419529 creator A5033199845 @default.
• W2122419529 creator A5038414554 @default.
• W2122419529 creator A5042877654 @default.
• W2122419529 creator A5046201209 @default.
• W2122419529 creator A5047695175 @default.
• W2122419529 creator A5071728727 @default.
• W2122419529 creator A5082443535 @default.
• W2122419529 creator A5086674805 @default.
• W2122419529 creator A5087473873 @default.
• W2122419529 creator A5089696388 @default.
• W2122419529 date "2012-07-15" @default.
• W2122419529 modified "2023-10-18" @default.
• W2122419529 title "CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma" @default.
• W2122419529 cites W1486740674 @default.
• W2122419529 cites W1493344427 @default.
• W2122419529 cites W1972009876 @default.
• W2122419529 cites W1988335934 @default.
• W2122419529 cites W1992492585 @default.
• W2122419529 cites W1993544268 @default.
• W2122419529 cites W2022293355 @default.
• W2122419529 cites W2030689322 @default.
• W2122419529 cites W2044330918 @default.
• W2122419529 cites W2044925392 @default.
• W2122419529 cites W2056907950 @default.
• W2122419529 cites W2071867803 @default.
• W2122419529 cites W2073767069 @default.
• W2122419529 cites W2077318471 @default.
• W2122419529 cites W2086943873 @default.
• W2122419529 cites W2093728029 @default.
• W2122419529 cites W2094573329 @default.
• W2122419529 cites W2098699177 @default.
• W2122419529 cites W2098992368 @default.
• W2122419529 cites W2103315206 @default.
• W2122419529 cites W2106787323 @default.
• W2122419529 cites W2113472355 @default.
• W2122419529 cites W2113879824 @default.
• W2122419529 cites W2133933675 @default.
• W2122419529 cites W2136682326 @default.
• W2122419529 cites W2155892126 @default.
• W2122419529 cites W2157269800 @default.
• W2122419529 cites W2162667703 @default.
• W2122419529 cites W2163403599 @default.
• W2122419529 cites W2167363836 @default.
• W2122419529 doi "https://doi.org/10.1158/0008-5472.can-11-4032" @default.
• W2122419529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22710437" @default.
• W2122419529 hasPublicationYear "2012" @default.
• W2122419529 type Work @default.
• W2122419529 sameAs 2122419529 @default.
• W2122419529 citedByCount "134" @default.
• W2122419529 countsByYear W21224195292012 @default.
• W2122419529 countsByYear W21224195292013 @default.
• W2122419529 countsByYear W21224195292014 @default.
• W2122419529 countsByYear W21224195292015 @default.
• W2122419529 countsByYear W21224195292016 @default.
• W2122419529 countsByYear W21224195292017 @default.
• W2122419529 countsByYear W21224195292018 @default.
• W2122419529 countsByYear W21224195292019 @default.
• W2122419529 countsByYear W21224195292020 @default.
• W2122419529 countsByYear W21224195292021 @default.
• W2122419529 countsByYear W21224195292022 @default.
• W2122419529 countsByYear W21224195292023 @default.
• W2122419529 crossrefType "journal-article" @default.
• W2122419529 hasAuthorship W2122419529A5002560091 @default.
• W2122419529 hasAuthorship W2122419529A5013799944 @default.
• W2122419529 hasAuthorship W2122419529A5015071376 @default.
• W2122419529 hasAuthorship W2122419529A5021073603 @default.
• W2122419529 hasAuthorship W2122419529A5029363724 @default.
• W2122419529 hasAuthorship W2122419529A5033199845 @default.
• W2122419529 hasAuthorship W2122419529A5038414554 @default.
• W2122419529 hasAuthorship W2122419529A5042877654 @default.
• W2122419529 hasAuthorship W2122419529A5046201209 @default.
• W2122419529 hasAuthorship W2122419529A5047695175 @default.
• W2122419529 hasAuthorship W2122419529A5071728727 @default.
• W2122419529 hasAuthorship W2122419529A5082443535 @default.
• W2122419529 hasAuthorship W2122419529A5086674805 @default.
• W2122419529 hasAuthorship W2122419529A5087473873 @default.
• W2122419529 hasAuthorship W2122419529A5089696388 @default.
• W2122419529 hasConcept C121608353 @default.
• W2122419529 hasConcept C126322002 @default.
• W2122419529 hasConcept C12823836 @default.
• W2122419529 hasConcept C13373296 @default.
• W2122419529 hasConcept C135576274 @default.
• W2122419529 hasConcept C143998085 @default.
• W2122419529 hasConcept C164027704 @default.
• W2122419529 hasConcept C170493617 @default.
• W2122419529 hasConcept C203014093 @default.
• W2122419529 hasConcept C2776107976 @default.
• W2122419529 hasConcept C2776914184 @default.
• W2122419529 hasConcept C2778019345 @default.
• W2122419529 hasConcept C2778690821 @default.
• W2122419529 hasConcept C2779013556 @default.

• next