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• W2122441400 endingPage "1878" @default.
• W2122441400 startingPage "1866" @default.
• W2122441400 abstract "ABSTRACT The Rex-1 ( Zfp-42 ) gene, which encodes an acidic zinc finger protein, is expressed at high levels in embryonic stem (ES) and F9 teratocarcinoma cells. Prior analysis identified an octamer motif in the Rex-1 promoter which is required for promoter activity in undifferentiated F9 cells and is involved in retinoic acid (RA)-associated reduction in expression. We show here that the Oct-3/4 transcription factor, but not Oct-1, can either activate or repress the Rex-1 promoter, depending on the cellular environment. Rex-1 repression is enhanced by E1A. The protein domain required for Oct-3/4 activation was mapped to amino acids 1 to 35, whereas the domain required for Oct-3/4 repression was mapped to amino acids 61 to 126, suggesting that the molecular mechanisms underlying transcriptional activation and repression differ. Like Oct-3/4, Oct-6 can also lower the expression of the Rex-1 promoter via the octamer site, and the amino-terminal portion of Oct-6 mediates this repression. In addition to the octamer motif, a novel positive regulatory element, located immediately 5′ of the octamer motif, was identified in the Rex-1 promoter. Mutations in this element greatly reduce Rex-1 promoter activity in F9 cells. High levels of a binding protein(s), designated Rox-1, recognize this novel DNA element in F9 cells, and this binding activity is reduced following RA treatment. Taken together, these results indicate that the Rex-1 promoter is regulated by specific octamer family members in early embryonic cells and that a novel element also contributes to Rex-1 expression." @default.
• W2122441400 created "2016-06-24" @default.
• W2122441400 creator A5030366259 @default.
• W2122441400 creator A5034110021 @default.
• W2122441400 creator A5053388072 @default.
• W2122441400 creator A5055444971 @default.
• W2122441400 date "1998-04-01" @default.
• W2122441400 modified "2023-10-11" @default.
• W2122441400 title "<i>Rex-1</i>, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site" @default.
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• W2122441400 doi "https://doi.org/10.1128/mcb.18.4.1866" @default.
• W2122441400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/121416" @default.
• W2122441400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9528758" @default.
• W2122441400 hasPublicationYear "1998" @default.
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