FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122487233> ?p ?o ?g. }

• W2122487233 endingPage "1367" @default.
• W2122487233 startingPage "1362" @default.
• W2122487233 abstract "Background Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown.Design and Methods We analyzed the clinical outcome of 78 newly diagnosed chronic phase patients, aged 16 or over, treated with imatinib 400 mg. Of these, 71 expressed either e13a2 or e14a2 transcripts. BCR-ABL transcripts were assayed by quantitative real-time polymerase chain reaction.Results After 12 months of treatment, 54% of the e14a2 patients had achieved a complete cytogenetic response, compared to 25% of the e13a2 patients (p=0.01). Kaplan-Meier analysis of the time to achieve complete cytogenetic response revealed that e14a2 patients had more rapid response rates, compared to e13a2 patients (p=0.006). e14a2 patients had a higher event-free survival rate in the first 12 months of treatment, although overall survival did not differ significantly between the patients with the two types of transcript. Human organic cation transporter protein 1 mRNA levels did not differ between the patients with the two types of transcript. The pre-treatment pCrKL/CrKL ratio (a surrogate marker of BCR-ABL tyrosine kinase activity) was higher in patients with e13a2 transcripts than in those with e14a2 (p=0.017).Conclusions Patients expressing the e14a2 transcript type have a higher rate and more rapid complete cytogenetic responses than e13a2-expressing patients, which may be due to higher BCR-ABL tyrosine kinase activity. Knowledge of the transcript type may yield additional prognostic information, although this requires testing on larger datasets." @default.
• W2122487233 created "2016-06-24" @default.
• W2122487233 creator A5003918662 @default.
• W2122487233 creator A5006525278 @default.
• W2122487233 creator A5011733008 @default.
• W2122487233 creator A5013531522 @default.
• W2122487233 creator A5054279766 @default.
• W2122487233 creator A5063461337 @default.
• W2122487233 creator A5072404159 @default.
• W2122487233 creator A5087816809 @default.
• W2122487233 date "2009-08-27" @default.
• W2122487233 modified "2023-10-10" @default.
• W2122487233 title "Chronic myeloid leukemia patients with the e13a2 BCR-ABL fusion transcript have inferior responses to imatinib compared to patients with the e14a2 transcript" @default.
• W2122487233 cites W1533139915 @default.
• W2122487233 cites W1799579309 @default.
• W2122487233 cites W1967920366 @default.
• W2122487233 cites W1976185876 @default.
• W2122487233 cites W1977728980 @default.
• W2122487233 cites W1992844715 @default.
• W2122487233 cites W1994571536 @default.
• W2122487233 cites W2016656445 @default.
• W2122487233 cites W2016953305 @default.
• W2122487233 cites W2037602803 @default.
• W2122487233 cites W2041053839 @default.
• W2122487233 cites W2044353890 @default.
• W2122487233 cites W2049426761 @default.
• W2122487233 cites W2057375535 @default.
• W2122487233 cites W2078634034 @default.
• W2122487233 cites W2107030941 @default.
• W2122487233 cites W2107153847 @default.
• W2122487233 cites W2118038386 @default.
• W2122487233 cites W2149298659 @default.
• W2122487233 cites W2151486690 @default.
• W2122487233 cites W2158884958 @default.
• W2122487233 cites W2410606477 @default.
• W2122487233 cites W2410647492 @default.
• W2122487233 cites W2579594561 @default.
• W2122487233 cites W2596224382 @default.
• W2122487233 cites W294399541 @default.
• W2122487233 doi "https://doi.org/10.3324/haematol.2009.009134" @default.
• W2122487233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754951" @default.
• W2122487233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19713230" @default.
• W2122487233 hasPublicationYear "2009" @default.
• W2122487233 type Work @default.
• W2122487233 sameAs 2122487233 @default.
• W2122487233 citedByCount "97" @default.
• W2122487233 countsByYear W21224872332012 @default.
• W2122487233 countsByYear W21224872332013 @default.
• W2122487233 countsByYear W21224872332014 @default.
• W2122487233 countsByYear W21224872332015 @default.
• W2122487233 countsByYear W21224872332016 @default.
• W2122487233 countsByYear W21224872332017 @default.
• W2122487233 countsByYear W21224872332018 @default.
• W2122487233 countsByYear W21224872332019 @default.
• W2122487233 countsByYear W21224872332020 @default.
• W2122487233 countsByYear W21224872332021 @default.
• W2122487233 countsByYear W21224872332022 @default.
• W2122487233 countsByYear W21224872332023 @default.
• W2122487233 crossrefType "journal-article" @default.
• W2122487233 hasAuthorship W2122487233A5003918662 @default.
• W2122487233 hasAuthorship W2122487233A5006525278 @default.
• W2122487233 hasAuthorship W2122487233A5011733008 @default.
• W2122487233 hasAuthorship W2122487233A5013531522 @default.
• W2122487233 hasAuthorship W2122487233A5054279766 @default.
• W2122487233 hasAuthorship W2122487233A5063461337 @default.
• W2122487233 hasAuthorship W2122487233A5072404159 @default.
• W2122487233 hasAuthorship W2122487233A5087816809 @default.
• W2122487233 hasBestOaLocation W21224872331 @default.
• W2122487233 hasConcept C104317684 @default.
• W2122487233 hasConcept C121608353 @default.
• W2122487233 hasConcept C125418893 @default.
• W2122487233 hasConcept C126322002 @default.
• W2122487233 hasConcept C138626823 @default.
• W2122487233 hasConcept C143998085 @default.
• W2122487233 hasConcept C170493617 @default.
• W2122487233 hasConcept C2777583451 @default.
• W2122487233 hasConcept C2778274637 @default.
• W2122487233 hasConcept C2778729363 @default.
• W2122487233 hasConcept C2778820342 @default.
• W2122487233 hasConcept C42362537 @default.
• W2122487233 hasConcept C43907098 @default.
• W2122487233 hasConcept C502942594 @default.
• W2122487233 hasConcept C54355233 @default.
• W2122487233 hasConcept C71924100 @default.
• W2122487233 hasConcept C86803240 @default.
• W2122487233 hasConceptScore W2122487233C104317684 @default.
• W2122487233 hasConceptScore W2122487233C121608353 @default.
• W2122487233 hasConceptScore W2122487233C125418893 @default.
• W2122487233 hasConceptScore W2122487233C126322002 @default.
• W2122487233 hasConceptScore W2122487233C138626823 @default.
• W2122487233 hasConceptScore W2122487233C143998085 @default.
• W2122487233 hasConceptScore W2122487233C170493617 @default.
• W2122487233 hasConceptScore W2122487233C2777583451 @default.
• W2122487233 hasConceptScore W2122487233C2778274637 @default.
• W2122487233 hasConceptScore W2122487233C2778729363 @default.
• W2122487233 hasConceptScore W2122487233C2778820342 @default.
• W2122487233 hasConceptScore W2122487233C42362537 @default.
• W2122487233 hasConceptScore W2122487233C43907098 @default.

• next