Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122520819> ?p ?o ?g. }
- W2122520819 endingPage "864" @default.
- W2122520819 startingPage "845" @default.
- W2122520819 abstract "Thromboembolic diseases are a major cause of morbidity and mortality, particularly in the Western world, which has stimulated enormous research efforts by the pharmaceutical industry to introduce new antithrombotic therapies. One strategy is the development of direct inhibitors of the serine protease thrombin, which holds a central position in the final steps of the blood coagulation cascade and in platelet activation. At present there is only limited clinical use of some parenteral preparations of thrombin inhibitors in acute situations, especially when the common antithrombotic drugs heparin, warfarin and aspirin are ineffective or associated with side effects. However, for use in prophylaxis of thrombotic diseases such inhibitors should be orally available, must be safe to avoid bleeding complications and should have an appropriate half-life, allowing once or twice daily dosing to maintain adequate antithrombotically effective blood levels. Details of several new and potent thrombin inhibitors have been published during the last years. For some of them oral bioavailability is claimed and they are effective in in vitro coagulation assays. However, most of them showed only limited efficacy in animal studies with respect to the doses administered. For that reason, effort is concentrated on the evaluation and optimisation of the overall physicochemical characteristics of the inhibitors in order to improve the pharmacokinetics and, thus, the development of promising drug candidates. Nevertheless, only careful clinical studies can give clear answers about the true therapeutical benefit of new developments in this field. This review summarises the current status of direct thrombin inhibitors which are already in clinical use and clinical development and gives an overview on recently published and promising new compounds." @default.
- W2122520819 created "2016-06-24" @default.
- W2122520819 creator A5069108662 @default.
- W2122520819 creator A5070053749 @default.
- W2122520819 creator A5078628197 @default.
- W2122520819 date "2001-05-01" @default.
- W2122520819 modified "2023-10-04" @default.
- W2122520819 title "Advances in the development of thrombin inhibitors" @default.
- W2122520819 cites W111617192 @default.
- W2122520819 cites W116242010 @default.
- W2122520819 cites W138588178 @default.
- W2122520819 cites W1513942883 @default.
- W2122520819 cites W1546549579 @default.
- W2122520819 cites W1592984308 @default.
- W2122520819 cites W1593430977 @default.
- W2122520819 cites W1715733843 @default.
- W2122520819 cites W1775065314 @default.
- W2122520819 cites W1916694280 @default.
- W2122520819 cites W1965540893 @default.
- W2122520819 cites W1966161117 @default.
- W2122520819 cites W1967128898 @default.
- W2122520819 cites W1967927771 @default.
- W2122520819 cites W1970117781 @default.
- W2122520819 cites W1970168995 @default.
- W2122520819 cites W1971119013 @default.
- W2122520819 cites W1971696680 @default.
- W2122520819 cites W1972222576 @default.
- W2122520819 cites W1973672016 @default.
- W2122520819 cites W1973689793 @default.
- W2122520819 cites W1973737489 @default.
- W2122520819 cites W1975773321 @default.
- W2122520819 cites W1977092655 @default.
- W2122520819 cites W1977434798 @default.
- W2122520819 cites W1978215762 @default.
- W2122520819 cites W1980037107 @default.
- W2122520819 cites W1986822871 @default.
- W2122520819 cites W1999221277 @default.
- W2122520819 cites W2002950074 @default.
- W2122520819 cites W2003409814 @default.
- W2122520819 cites W2006103451 @default.
- W2122520819 cites W2010837364 @default.
- W2122520819 cites W2011065673 @default.
- W2122520819 cites W2011794265 @default.
- W2122520819 cites W2014688096 @default.
- W2122520819 cites W2021121042 @default.
- W2122520819 cites W2021497410 @default.
- W2122520819 cites W2022149323 @default.
- W2122520819 cites W2028015715 @default.
- W2122520819 cites W2028391605 @default.
- W2122520819 cites W2030328556 @default.
- W2122520819 cites W2034789104 @default.
- W2122520819 cites W2034931168 @default.
- W2122520819 cites W2035500856 @default.
- W2122520819 cites W2036872916 @default.
- W2122520819 cites W2037245436 @default.
- W2122520819 cites W2039356047 @default.
- W2122520819 cites W2040044816 @default.
- W2122520819 cites W2040289040 @default.
- W2122520819 cites W2040717162 @default.
- W2122520819 cites W2040912042 @default.
- W2122520819 cites W2045779964 @default.
- W2122520819 cites W2045865674 @default.
- W2122520819 cites W2048032060 @default.
- W2122520819 cites W2050940330 @default.
- W2122520819 cites W2051657050 @default.
- W2122520819 cites W2055844415 @default.
- W2122520819 cites W2058196026 @default.
- W2122520819 cites W2058310514 @default.
- W2122520819 cites W2064643750 @default.
- W2122520819 cites W2065904398 @default.
- W2122520819 cites W2071184125 @default.
- W2122520819 cites W2072212700 @default.
- W2122520819 cites W2080738816 @default.
- W2122520819 cites W2099635185 @default.
- W2122520819 cites W2100065401 @default.
- W2122520819 cites W2103073050 @default.
- W2122520819 cites W2115034100 @default.
- W2122520819 cites W2119708848 @default.
- W2122520819 cites W2122121359 @default.
- W2122520819 cites W2127536162 @default.
- W2122520819 cites W2141373630 @default.
- W2122520819 cites W2144586257 @default.
- W2122520819 cites W2152504952 @default.
- W2122520819 cites W2153555369 @default.
- W2122520819 cites W2157772541 @default.
- W2122520819 cites W2162356386 @default.
- W2122520819 cites W2195067056 @default.
- W2122520819 cites W2221026318 @default.
- W2122520819 cites W2337880179 @default.
- W2122520819 cites W2419354132 @default.
- W2122520819 cites W2470763031 @default.
- W2122520819 cites W2917028849 @default.
- W2122520819 cites W2949075749 @default.
- W2122520819 cites W2949738102 @default.
- W2122520819 cites W2951410279 @default.
- W2122520819 cites W2951796570 @default.
- W2122520819 cites W2952115519 @default.
- W2122520819 cites W39129212 @default.