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• W2122534935 startingPage "4103" @default.
• W2122534935 abstract "Abstract The development of Th subset is accompanied by subset-specific chromatin remodeling of cytokine gene loci. In this study, we show that the C-terminal, but not the N-terminal zinc finger (N-finger) of GATA-3 mediates the association with the IL-4/IL-13 intergenic DNase I hypersensitive site and the induction of an extended DNase I hypersensitivity on the IL-4/IL-13 locus. Consistently, deletion of the transactivation domains or the C-finger, but not the N-finger, abrogated the induction of IL-4 and IL-13 as well as the down-regulation of IFN-γ. In contrast, the N-finger of GATA-3 was indispensable for the binding to the IL-5 promoter and the induction of IL-5. The selective use of the N-finger may underlie the differential roles of GATA-3 in the induction of IL-4, IL-13, and IL-5." @default.
• W2122534935 created "2016-06-24" @default.
• W2122534935 creator A5038279029 @default.
• W2122534935 creator A5065692230 @default.
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• W2122534935 date "2002-10-15" @default.
• W2122534935 modified "2023-10-17" @default.
• W2122534935 title "Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development" @default.
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• W2122534935 doi "https://doi.org/10.4049/jimmunol.169.8.4103" @default.
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