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• W2122577020 abstract "Our models for detecting the effect of adaptation on population genomic diversity are often predicated on a single newly arisen mutation sweeping rapidly to fixation. However, a population can also adapt to a new situation by multiple mutations of similar phenotypic effect that arise in parallel. These mutations can each quickly reach intermediate frequency, preventing any single one from rapidly sweeping to fixation globally (a soft sweep). Here we study models of parallel mutation in a geographically spread population adapting to a global selection pressure. The slow geographic spread of a selected allele can allow other selected alleles to arise and spread elsewhere in the species range. When these different selected alleles meet, their spread can slow dramatically, and so form a geographic patchwork which could be mistaken for a signal of local adaptation. This random spatial tessellation will dissipate over time due to mixing by migration, leaving a set of partial sweeps within the global population. We show that the spatial tessellation initially formed by mutational types is closely connected to Poisson process models of crystallization, which we extend. We find that the probability of parallel mutation and the spatial scale on which parallel mutation occurs is captured by a single characteristic length that reflects the expected distance a spreading allele travels before it encounters a different spreading allele. This characteristic length depends on the mutation rate, the dispersal parameter, the effective local density of individuals, and to a much lesser extent the strength of selection. We argue that even in widely dispersing species, such parallel geographic sweeps may be surprisingly common. Thus, we predict, as more data becomes available, many more examples of intra-species parallel adaptation will be uncovered." @default.
• W2122577020 created "2016-06-24" @default.
• W2122577020 creator A5021950882 @default.
• W2122577020 creator A5044378657 @default.
• W2122577020 date "2010-10-01" @default.
• W2122577020 modified "2023-10-11" @default.
• W2122577020 title "Parallel Adaptation: One or Many Waves of Advance of an Advantageous Allele?" @default.
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• W2122577020 doi "https://doi.org/10.1534/genetics.110.119594" @default.
• W2122577020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2954473" @default.
• W2122577020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20660645" @default.
• W2122577020 hasPublicationYear "2010" @default.
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