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- W2122597764 abstract "The human immunodeficiency virus type 2 (HIV-2) was detected in countries of Western Africa and it is another cause of the Acquired Immunodeficiency Syndrome (AIDS). The env gene encodes the synthesis of the precursor gp140 protein that is cleaved by the virus protease into two proteins: gp36 and gp105. The synthetic peptides and recombinant proteins of the transmembrane gp36 glycoprotein show a high reactivity and specificity in the detection of antibodies in samples of infected patients, for what they are broadly used in the HIV-2 immunodiagnosis. In the present work the reactivity of a synthetic peptide gp36 (5) (585-610) and the recombinant protein gp36 from transmembrane region of HIV-2 were tested with 15 positive samples of HIV-2. In order to assess specificity of those antigens, 74 sera from seropositive Cuban people to HIV-1 and 30 samples from healthy blood donors were tested. UMELISA HIV 1+2 Recombinant assay (TecnoSUMA International S.A., Cuba) was used as a reference for the detection of antibodies to HIV 1 and 2. All the samples used in the study were confirmed by Western Blot assay. Sensitivity for both antigens was 100 %. The synthetic peptide gp36 (5) didn't detect the positive samples of the HIV-1 evaluated, contrary to the recombinant protein that detected 46 % of the samples. Specificity for both antigens was 100 % with the samples from healthy blood donors. This study demonstrated the high reactivity of the recombinant protein and the synthetic peptide, and the high specificity of this last one with HIV-2 positive samples." @default.
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- W2122597764 date "2009-01-01" @default.
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- W2122597764 title "Comparación de la antigenicidad de dos péptidos sintéticos y una proteína recombinante de la región de transmembrana (gp21) del HTLV-I" @default.
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