FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122602945> ?p ?o ?g. }

• W2122602945 endingPage "577" @default.
• W2122602945 startingPage "571" @default.
• W2122602945 abstract "Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine the plasma pharmacokinetic profile of enantiomers of PQ and carboxyprimaquine (cPQ), the major plasma metabolite. The individuals were orally administered PQ diphosphate, equivalent to 45-mg base, 30 minutes after a normal breakfast. Blood samples were collected at different time intervals, and plasma samples were analyzed for enantiomers of PQ and cPQ. Plasma PQ concentrations were low and variable for both parent enantiomers and peaked around 2-4 hours. Peak (-)-(R)-PQ concentrations ranged from 121 ng/ml to 221 ng/ml, and peak (+)-(S)-PQ concentrations ranged from 168 ng/ml to 299 ng/ml. The cPQ concentrations were much higher and were surprisingly consistent from subject to subject. Essentially all the cPQ detected in plasma was (-)-cPQ. The peak concentrations of (-)-cPQ were observed at 8 hours (range: 1104-1756 ng/ml); however, very high concentrations were sustained through 24 hours. (+)-cPQ was two orders of magnitude lower than (-)-cPQ, and in a few subjects it was detected but only under the limit of quantification. In vitro studies with primary human hepatocytes also suggested more rapid metabolism of (-)-PQ compared with (+)-PQ. The results suggest more rapid metabolism of (-)-PQ to (-) cPQ compared with (+)-PQ. Alternatively, (+)-PQ or (+)-cPQ could be rapidly converted to another metabolite(s) or distributed to tissues. This is the first clinical report on enantioselective pharmacokinetic profiles of PQ and cPQ and supports further clinical evaluation of individual PQ enantiomers." @default.
• W2122602945 created "2016-06-24" @default.
• W2122602945 creator A5002083327 @default.
• W2122602945 creator A5014644608 @default.
• W2122602945 creator A5018778280 @default.
• W2122602945 creator A5035849994 @default.
• W2122602945 creator A5039173092 @default.
• W2122602945 creator A5044228837 @default.
• W2122602945 creator A5046094471 @default.
• W2122602945 creator A5049082763 @default.
• W2122602945 creator A5051860282 @default.
• W2122602945 creator A5062001713 @default.
• W2122602945 creator A5064602133 @default.
• W2122602945 creator A5074463351 @default.
• W2122602945 creator A5087656284 @default.
• W2122602945 creator A5090532505 @default.
• W2122602945 creator A5090576009 @default.
• W2122602945 date "2015-01-30" @default.
• W2122602945 modified "2023-09-27" @default.
• W2122602945 title "Enantioselective Pharmacokinetics of Primaquine in Healthy Human Volunteers" @default.
• W2122602945 cites W129057228 @default.
• W2122602945 cites W1491184535 @default.
• W2122602945 cites W1496355881 @default.
• W2122602945 cites W1950127504 @default.
• W2122602945 cites W1965872090 @default.
• W2122602945 cites W196833282 @default.
• W2122602945 cites W1972258253 @default.
• W2122602945 cites W1973828942 @default.
• W2122602945 cites W1981241430 @default.
• W2122602945 cites W1981634957 @default.
• W2122602945 cites W1987474216 @default.
• W2122602945 cites W2004295690 @default.
• W2122602945 cites W2008616614 @default.
• W2122602945 cites W201127736 @default.
• W2122602945 cites W2012004578 @default.
• W2122602945 cites W2024171245 @default.
• W2122602945 cites W2029470741 @default.
• W2122602945 cites W2033714462 @default.
• W2122602945 cites W2037912215 @default.
• W2122602945 cites W2047383052 @default.
• W2122602945 cites W2047506346 @default.
• W2122602945 cites W2047761142 @default.
• W2122602945 cites W2058846932 @default.
• W2122602945 cites W2062432044 @default.
• W2122602945 cites W2064737238 @default.
• W2122602945 cites W2065776977 @default.
• W2122602945 cites W2068476392 @default.
• W2122602945 cites W2071249915 @default.
• W2122602945 cites W2073823026 @default.
• W2122602945 cites W2083056229 @default.
• W2122602945 cites W2085597837 @default.
• W2122602945 cites W2089172952 @default.
• W2122602945 cites W2089897660 @default.
• W2122602945 cites W2107291528 @default.
• W2122602945 cites W2107403206 @default.
• W2122602945 cites W2108367840 @default.
• W2122602945 cites W2117767554 @default.
• W2122602945 cites W2129334038 @default.
• W2122602945 cites W2137930030 @default.
• W2122602945 cites W2161252729 @default.
• W2122602945 cites W28046097 @default.
• W2122602945 cites W935561695 @default.
• W2122602945 cites W94336553 @default.
• W2122602945 doi "https://doi.org/10.1124/dmd.114.061127" @default.
• W2122602945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25637634" @default.
• W2122602945 hasPublicationYear "2015" @default.
• W2122602945 type Work @default.
• W2122602945 sameAs 2122602945 @default.
• W2122602945 citedByCount "22" @default.
• W2122602945 countsByYear W21226029452016 @default.
• W2122602945 countsByYear W21226029452017 @default.
• W2122602945 countsByYear W21226029452018 @default.
• W2122602945 countsByYear W21226029452019 @default.
• W2122602945 countsByYear W21226029452020 @default.
• W2122602945 countsByYear W21226029452021 @default.
• W2122602945 countsByYear W21226029452022 @default.
• W2122602945 countsByYear W21226029452023 @default.
• W2122602945 crossrefType "journal-article" @default.
• W2122602945 hasAuthorship W2122602945A5002083327 @default.
• W2122602945 hasAuthorship W2122602945A5014644608 @default.
• W2122602945 hasAuthorship W2122602945A5018778280 @default.
• W2122602945 hasAuthorship W2122602945A5035849994 @default.
• W2122602945 hasAuthorship W2122602945A5039173092 @default.
• W2122602945 hasAuthorship W2122602945A5044228837 @default.
• W2122602945 hasAuthorship W2122602945A5046094471 @default.
• W2122602945 hasAuthorship W2122602945A5049082763 @default.
• W2122602945 hasAuthorship W2122602945A5051860282 @default.
• W2122602945 hasAuthorship W2122602945A5062001713 @default.
• W2122602945 hasAuthorship W2122602945A5064602133 @default.
• W2122602945 hasAuthorship W2122602945A5074463351 @default.
• W2122602945 hasAuthorship W2122602945A5087656284 @default.
• W2122602945 hasAuthorship W2122602945A5090532505 @default.
• W2122602945 hasAuthorship W2122602945A5090576009 @default.
• W2122602945 hasBestOaLocation W21226029451 @default.
• W2122602945 hasConcept C112705442 @default.
• W2122602945 hasConcept C185592680 @default.
• W2122602945 hasConcept C203014093 @default.
• W2122602945 hasConcept C2776793103 @default.

• next