FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122613732> ?p ?o ?g. }

• W2122613732 endingPage "169" @default.
• W2122613732 startingPage "161" @default.
• W2122613732 abstract "The tumor suppressor protein p53 plays an important role in recognition of DNA damage and induction of subsequent cell cycle arrest. One of its target genes encodes the protein p21WAF1, which is involved in mediation of growth arrest after DNA damage has occurred. Dibenzo[a,l]pyrene (DB[a,l]P) is a polycyclic aromatic hydrocarbon which is an exceptionally potent carcinogen. A reactive secondary metabolite of DB[a,l]P, the fjord region (–)-anti-11R,12S-dihydrodiol 13R,14S-epoxide [(–)-anti-DB[a,l]PDE] was used to investigate DNA damage via adduct formation and cell cycle arrest in human diploid fibroblast cell cultures (HDF). Synchronous HDF were exposed to increasing concentrations (0.014, 0.028 and 0.07 μM) of (-)-anti-DB[a,l]PDE and at 1, 12, 24 and 42 h after treatment cell pellets were analyzed for DNA adduct formation and cell cycle arrest. Exposure of HDF to 0.07 μM (–)-anti-DB[a,l]PDE caused a total DNA binding level of 113 pmol adducts/mg DNA (42 h after treatment). G1 arrest was induced by this treatment, with 91% of the cells remaining in G1 phase compared with the solvent-treated control cultures (50%) as analyzed by propidium iodide staining and flow cytometry. Further investigation of the percentage of cells in S phase by 5-bromo-2′-deoxyuridine incorporation confirmed the G1 arrest in HDF treated with 0.07 μM (–)-anti-DB[a,l]PDE, with only 1.5% of the cells moving into S phase compared with 39% in the control 42 h after treatment. Induction of p53 and p21WAF1 was demonstrated by western blot analysis." @default.
• W2122613732 created "2016-06-24" @default.
• W2122613732 creator A5026277311 @default.
• W2122613732 creator A5033888217 @default.
• W2122613732 creator A5042094715 @default.
• W2122613732 creator A5058407421 @default.
• W2122613732 creator A5079625917 @default.
• W2122613732 date "2001-01-01" @default.
• W2122613732 modified "2023-09-29" @default.
• W2122613732 title "Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts" @default.
• W2122613732 cites W130569595 @default.
• W2122613732 cites W1502887285 @default.
• W2122613732 cites W1594700207 @default.
• W2122613732 cites W1847864430 @default.
• W2122613732 cites W1945199494 @default.
• W2122613732 cites W194800238 @default.
• W2122613732 cites W1966592073 @default.
• W2122613732 cites W1970149024 @default.
• W2122613732 cites W1989734490 @default.
• W2122613732 cites W1992836428 @default.
• W2122613732 cites W1996033279 @default.
• W2122613732 cites W2004988801 @default.
• W2122613732 cites W2014120293 @default.
• W2122613732 cites W2017418899 @default.
• W2122613732 cites W2022447460 @default.
• W2122613732 cites W2024321399 @default.
• W2122613732 cites W2030283142 @default.
• W2122613732 cites W2042182009 @default.
• W2122613732 cites W2047658021 @default.
• W2122613732 cites W2047878898 @default.
• W2122613732 cites W2054114446 @default.
• W2122613732 cites W2054836547 @default.
• W2122613732 cites W2056303147 @default.
• W2122613732 cites W2070165132 @default.
• W2122613732 cites W2076554945 @default.
• W2122613732 cites W2083265253 @default.
• W2122613732 cites W2084147994 @default.
• W2122613732 cites W2085738604 @default.
• W2122613732 cites W2089277080 @default.
• W2122613732 cites W2090025028 @default.
• W2122613732 cites W2100181755 @default.
• W2122613732 cites W2116452745 @default.
• W2122613732 cites W2135535670 @default.
• W2122613732 cites W2144232168 @default.
• W2122613732 cites W2153089799 @default.
• W2122613732 cites W2160632391 @default.
• W2122613732 cites W2163565167 @default.
• W2122613732 cites W2188321461 @default.
• W2122613732 cites W2323366367 @default.
• W2122613732 cites W2399183061 @default.
• W2122613732 doi "https://doi.org/10.1093/carcin/22.1.161" @default.
• W2122613732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11159755" @default.
• W2122613732 hasPublicationYear "2001" @default.
• W2122613732 type Work @default.
• W2122613732 sameAs 2122613732 @default.
• W2122613732 citedByCount "21" @default.
• W2122613732 countsByYear W21226137322013 @default.
• W2122613732 countsByYear W21226137322016 @default.
• W2122613732 crossrefType "journal-article" @default.
• W2122613732 hasAuthorship W2122613732A5026277311 @default.
• W2122613732 hasAuthorship W2122613732A5033888217 @default.
• W2122613732 hasAuthorship W2122613732A5042094715 @default.
• W2122613732 hasAuthorship W2122613732A5058407421 @default.
• W2122613732 hasAuthorship W2122613732A5079625917 @default.
• W2122613732 hasBestOaLocation W21226137321 @default.
• W2122613732 hasConcept C105696609 @default.
• W2122613732 hasConcept C114246631 @default.
• W2122613732 hasConcept C143425029 @default.
• W2122613732 hasConcept C1491633281 @default.
• W2122613732 hasConcept C153911025 @default.
• W2122613732 hasConcept C185592680 @default.
• W2122613732 hasConcept C190283241 @default.
• W2122613732 hasConcept C2775934118 @default.
• W2122613732 hasConcept C2777477808 @default.
• W2122613732 hasConcept C2777538855 @default.
• W2122613732 hasConcept C2781247443 @default.
• W2122613732 hasConcept C29537977 @default.
• W2122613732 hasConcept C31573885 @default.
• W2122613732 hasConcept C552990157 @default.
• W2122613732 hasConcept C553184892 @default.
• W2122613732 hasConcept C55493867 @default.
• W2122613732 hasConcept C86803240 @default.
• W2122613732 hasConceptScore W2122613732C105696609 @default.
• W2122613732 hasConceptScore W2122613732C114246631 @default.
• W2122613732 hasConceptScore W2122613732C143425029 @default.
• W2122613732 hasConceptScore W2122613732C1491633281 @default.
• W2122613732 hasConceptScore W2122613732C153911025 @default.
• W2122613732 hasConceptScore W2122613732C185592680 @default.
• W2122613732 hasConceptScore W2122613732C190283241 @default.
• W2122613732 hasConceptScore W2122613732C2775934118 @default.
• W2122613732 hasConceptScore W2122613732C2777477808 @default.
• W2122613732 hasConceptScore W2122613732C2777538855 @default.
• W2122613732 hasConceptScore W2122613732C2781247443 @default.
• W2122613732 hasConceptScore W2122613732C29537977 @default.
• W2122613732 hasConceptScore W2122613732C31573885 @default.
• W2122613732 hasConceptScore W2122613732C552990157 @default.
• W2122613732 hasConceptScore W2122613732C553184892 @default.
• W2122613732 hasConceptScore W2122613732C55493867 @default.

• next