FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122643576> ?p ?o ?g. }

• W2122643576 endingPage "174" @default.
• W2122643576 startingPage "163" @default.
• W2122643576 abstract "Exposure to the environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), produces hydronephrosis in developing mice, the etiology of which involves hyperplasia within the ureteric luminal epithelium. Dysregulation of epidermal growth factor receptor (EGFR), EGF, and transforming growth factor-α expression has been implicated as playing a role in TCDD-induced hydronephrosis. In this study, changes in the expression of genes encoding the EGFR and its cognate ligands in response to TCDD were evaluated within the developing ureter. C57BL/6 dams were injected ip with 30 μg/kg TCDD on gestational day (GD) 13 or 16 and fetal tissues removed on GD 17. Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator messenger RNA (mRNA) were expressed in control and treated fetal tissues at GD 14 and 17. Prototypical AHR target genes, Cyp1a1, Cyp1a2, and Cyp1b1 were upregulated in TCDD-exposed fetal tissues, demonstrating AHR transcriptional activity at these developmental stages. Amphiregulin (AREG) and epiregulin, ligands for the EGFR, were induced at the transcriptional level in ureters of fetuses exposed to TCDD for 24 h. AREG mRNA was also induced by TCDD dose- and time-dependently in the mouse hepatoma cell line Hepa-1c1c7 (Hepa-1), mimicking the induction patterns of CYP1A1 mRNA. Other AHR ligands also induced AREG mRNA in Hepa-1 cells. Furthermore, variant Hepa-1 cells (TAOBPrc1 cells) virtually deficient in the AHR failed to display an increase in AREG mRNA in response to TCDD. Taken together, these data suggest that the AHR cross talks with the EGFR signaling pathway by directly inducing the expression of growth factors that are important for EGFR signaling in the developing mouse ureter." @default.
• W2122643576 created "2016-06-24" @default.
• W2122643576 creator A5002074913 @default.
• W2122643576 creator A5012614332 @default.
• W2122643576 creator A5062535878 @default.
• W2122643576 date "2006-06-13" @default.
• W2122643576 modified "2023-10-15" @default.
• W2122643576 title "In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Amphiregulin Gene Expression in the Developing Mouse Ureter" @default.
• W2122643576 cites W1486593521 @default.
• W2122643576 cites W1584392981 @default.
• W2122643576 cites W1652104347 @default.
• W2122643576 cites W1917370654 @default.
• W2122643576 cites W1967071130 @default.
• W2122643576 cites W1969682160 @default.
• W2122643576 cites W1969754449 @default.
• W2122643576 cites W1973368322 @default.
• W2122643576 cites W1977688415 @default.
• W2122643576 cites W198065351 @default.
• W2122643576 cites W1981535636 @default.
• W2122643576 cites W1985754063 @default.
• W2122643576 cites W1988514662 @default.
• W2122643576 cites W1997498933 @default.
• W2122643576 cites W1998928723 @default.
• W2122643576 cites W2006745607 @default.
• W2122643576 cites W2011642803 @default.
• W2122643576 cites W2014004590 @default.
• W2122643576 cites W2015837282 @default.
• W2122643576 cites W2022067368 @default.
• W2122643576 cites W2022422012 @default.
• W2122643576 cites W2022645849 @default.
• W2122643576 cites W2024564719 @default.
• W2122643576 cites W2026576106 @default.
• W2122643576 cites W2033320686 @default.
• W2122643576 cites W2034831859 @default.
• W2122643576 cites W2041026780 @default.
• W2122643576 cites W2054898146 @default.
• W2122643576 cites W2059382320 @default.
• W2122643576 cites W2059709609 @default.
• W2122643576 cites W2066057639 @default.
• W2122643576 cites W2067376187 @default.
• W2122643576 cites W2069306306 @default.
• W2122643576 cites W2075006146 @default.
• W2122643576 cites W2077668550 @default.
• W2122643576 cites W2090556821 @default.
• W2122643576 cites W2090629019 @default.
• W2122643576 cites W2100583527 @default.
• W2122643576 cites W2102820063 @default.
• W2122643576 cites W2104835186 @default.
• W2122643576 cites W2110278880 @default.
• W2122643576 cites W2119409275 @default.
• W2122643576 cites W2123206362 @default.
• W2122643576 cites W2128603046 @default.
• W2122643576 cites W2132762752 @default.
• W2122643576 cites W2134048254 @default.
• W2122643576 cites W2136655543 @default.
• W2122643576 cites W2143633028 @default.
• W2122643576 cites W2150109695 @default.
• W2122643576 cites W2157688061 @default.
• W2122643576 cites W2158412843 @default.
• W2122643576 cites W2159197741 @default.
• W2122643576 cites W2160811937 @default.
• W2122643576 cites W2171196252 @default.
• W2122643576 cites W2218340297 @default.
• W2122643576 cites W2396068152 @default.
• W2122643576 cites W2411319600 @default.
• W2122643576 doi "https://doi.org/10.1093/toxsci/kfl090" @default.
• W2122643576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16929009" @default.
• W2122643576 hasPublicationYear "2006" @default.
• W2122643576 type Work @default.
• W2122643576 sameAs 2122643576 @default.
• W2122643576 citedByCount "34" @default.
• W2122643576 countsByYear W21226435762012 @default.
• W2122643576 countsByYear W21226435762013 @default.
• W2122643576 countsByYear W21226435762014 @default.
• W2122643576 countsByYear W21226435762016 @default.
• W2122643576 countsByYear W21226435762019 @default.
• W2122643576 countsByYear W21226435762020 @default.
• W2122643576 countsByYear W21226435762021 @default.
• W2122643576 countsByYear W21226435762023 @default.
• W2122643576 crossrefType "journal-article" @default.
• W2122643576 hasAuthorship W2122643576A5002074913 @default.
• W2122643576 hasAuthorship W2122643576A5012614332 @default.
• W2122643576 hasAuthorship W2122643576A5062535878 @default.
• W2122643576 hasBestOaLocation W21226435761 @default.
• W2122643576 hasConcept C104317684 @default.
• W2122643576 hasConcept C126322002 @default.
• W2122643576 hasConcept C134018914 @default.
• W2122643576 hasConcept C150194340 @default.
• W2122643576 hasConcept C170493617 @default.
• W2122643576 hasConcept C185592680 @default.
• W2122643576 hasConcept C2776362946 @default.
• W2122643576 hasConcept C2777968868 @default.
• W2122643576 hasConcept C2779438470 @default.
• W2122643576 hasConcept C2780806702 @default.
• W2122643576 hasConcept C33594762 @default.
• W2122643576 hasConcept C45815257 @default.
• W2122643576 hasConcept C55493867 @default.
• W2122643576 hasConcept C71924100 @default.

• next