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- W2122649894 abstract "Mammary phyllodes tumours (PTs) are rare fibroepithelial neoplasms of the breast. They have a propensity to recur locally and the ability to metastasise. There is some correlation between the histological parameters of PTs and their biological behaviour; however, no single feature or grading scheme can accurately predict the behaviour of a PT. The PTs that will recur and/or metastasise are not being precisely delineated with the currently available diagnostic tools. A number of pathways/markers have been implicated in the pathogenesis of PTs including hormone receptors, members of the Wnt pathway, cell cycle proteins, factors involved in angiogenesis, tyrosine kinase receptors and matrix metalloproteases. The currently available evidence supports a model where initiation of PTs involves interactions between the epithelium and stroma and these interactions are lost with the progression to malignancy such that growth of the stroma becomes autonomous of the epithelium. Loss of the stromal-epithelial interdependancy, increased stromal proliferation, angiogenesis and matrix alterations appear to be involved in the progression to malignancy." @default.
- W2122649894 created "2016-06-24" @default.
- W2122649894 creator A5002985052 @default.
- W2122649894 creator A5025732084 @default.
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- W2122649894 creator A5070948162 @default.
- W2122649894 creator A5083653505 @default.
- W2122649894 creator A5085208248 @default.
- W2122649894 date "2009-02-01" @default.
- W2122649894 modified "2023-10-06" @default.
- W2122649894 title "Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumours" @default.
- W2122649894 cites W1482829962 @default.
- W2122649894 cites W1547849202 @default.
- W2122649894 cites W1966064536 @default.
- W2122649894 cites W1966134529 @default.
- W2122649894 cites W1968393570 @default.
- W2122649894 cites W1969340706 @default.
- W2122649894 cites W1971324961 @default.
- W2122649894 cites W1971512164 @default.
- W2122649894 cites W1976410247 @default.
- W2122649894 cites W1976988154 @default.
- W2122649894 cites W1977706798 @default.
- W2122649894 cites W1983575720 @default.
- W2122649894 cites W1984061522 @default.
- W2122649894 cites W1986057432 @default.
- W2122649894 cites W1990485010 @default.
- W2122649894 cites W1999112733 @default.
- W2122649894 cites W2000007799 @default.
- W2122649894 cites W2000159893 @default.
- W2122649894 cites W2002325840 @default.
- W2122649894 cites W2004375114 @default.
- W2122649894 cites W2005968088 @default.
- W2122649894 cites W2007649418 @default.
- W2122649894 cites W2007882469 @default.
- W2122649894 cites W2010162526 @default.
- W2122649894 cites W2011764975 @default.
- W2122649894 cites W2015408871 @default.
- W2122649894 cites W2015410427 @default.
- W2122649894 cites W2015495715 @default.
- W2122649894 cites W2015928820 @default.
- W2122649894 cites W2016538123 @default.
- W2122649894 cites W2017819822 @default.
- W2122649894 cites W2022810442 @default.
- W2122649894 cites W2023191382 @default.
- W2122649894 cites W2029008382 @default.
- W2122649894 cites W2030618323 @default.
- W2122649894 cites W2031126388 @default.
- W2122649894 cites W2032163139 @default.
- W2122649894 cites W2035254604 @default.
- W2122649894 cites W2035792794 @default.
- W2122649894 cites W2036539825 @default.
- W2122649894 cites W2036570549 @default.
- W2122649894 cites W2036752075 @default.
- W2122649894 cites W2037006724 @default.
- W2122649894 cites W2037769103 @default.
- W2122649894 cites W2038887939 @default.
- W2122649894 cites W2043311475 @default.
- W2122649894 cites W2046584436 @default.
- W2122649894 cites W2048212719 @default.
- W2122649894 cites W2048947582 @default.
- W2122649894 cites W2050365951 @default.
- W2122649894 cites W2052442194 @default.
- W2122649894 cites W2053369782 @default.
- W2122649894 cites W2055711778 @default.
- W2122649894 cites W2057504956 @default.
- W2122649894 cites W2058010748 @default.
- W2122649894 cites W2060695504 @default.
- W2122649894 cites W2062821569 @default.
- W2122649894 cites W2064003000 @default.
- W2122649894 cites W2064740362 @default.
- W2122649894 cites W2064956179 @default.
- W2122649894 cites W2071119950 @default.
- W2122649894 cites W2071569637 @default.
- W2122649894 cites W2073168217 @default.
- W2122649894 cites W2074550722 @default.
- W2122649894 cites W2075367853 @default.
- W2122649894 cites W2076719783 @default.
- W2122649894 cites W2078169871 @default.
- W2122649894 cites W2079891977 @default.
- W2122649894 cites W2081713398 @default.
- W2122649894 cites W2083456571 @default.
- W2122649894 cites W2084147994 @default.
- W2122649894 cites W2084258581 @default.
- W2122649894 cites W2085691361 @default.
- W2122649894 cites W2086451010 @default.
- W2122649894 cites W2088450692 @default.
- W2122649894 cites W2089268822 @default.
- W2122649894 cites W2095606804 @default.
- W2122649894 cites W2100481402 @default.
- W2122649894 cites W2107471637 @default.
- W2122649894 cites W2107838017 @default.
- W2122649894 cites W2112480698 @default.
- W2122649894 cites W2113159006 @default.
- W2122649894 cites W2117100349 @default.
- W2122649894 cites W2117470827 @default.
- W2122649894 cites W2118699895 @default.
- W2122649894 cites W2119092910 @default.
- W2122649894 cites W2121946977 @default.