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- W2122695097 abstract "Maropitant is a neurokinin‐1 inhibitor that acts to prevent and treat vomiting by blocking stimuli to the final common pathway in the emetic centre of the brain. The field efficacy and safety of a single oral dose of maropitant were investigated for the prevention of vomiting in dogs with a history of motion sickness resulting from transportation by car in two blinded, placebo‐controlled studies. In an exploratory study designed as a two‐way crossover trial with 17 dogs, 10 of the dogs given the placebo vomited during a car journey but only three of the dogs vomited under maropitant treatment. In a larger multicentred parallel design study, 69 of 105 dogs treated with the placebo vomited during the journey compared with 15 of 106 dogs treated with maropitant (P≤0·0001)." @default.
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- W2122695097 date "2007-09-01" @default.
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- W2122695097 title "Efficacy of maropitant for preventing vomiting associated with motion sickness in dogs" @default.
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- W2122695097 doi "https://doi.org/10.1136/vr.161.13.444" @default.
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