FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122710090> ?p ?o ?g. }

• W2122710090 endingPage "706" @default.
• W2122710090 startingPage "693" @default.
• W2122710090 abstract "1. Hensen's cells in the isolated cochlea were stimulated by extracellular adenosine 5'-triphosphate (ATP) applied to their endolymphatic surface while changes in membrane current and intracellular calcium concentration ([Ca2+]i) were measured simultaneously. The response consisted of (i) an initial rapid inward current accompanied by elevation of the [Ca2+]i, (ii) a more slowly rising inward current accompanied by a rise of the [Ca2+]i and (iii) a slowly developing reduction of input conductance. 2. The slower responses were maintained in the absence of extracellular Ca2+. Similar responses were produced by increasing the [Ca2+]i via UV flash photolysis of intracellular D-myo-inositol 1,4,5-trisphosphate, P4(5)-(1-(2-nitrophenyl)ethyl) ester (caged InsP3) loaded at pipette concentrations of 8-16 microM. 3. The slow inward current, reversing around 0 mV, was blocked by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). 4. Bath application of U-73122 (1 microM), a phospholipase C inhibitor, eliminated the slow Ca2+-release component of the response to ATP. It is proposed that the effects of ATP are mediated by the co-activation of ionotropic P2X and metabotropic P2Y receptors. 5. Immunohistochemistry using light and electron microscopy revealed that inositol 1,4,5-trisphosphate (InsP3) receptors delineate a network within the cells. 6. The coupling ratio (CR) between cell pairs measured in dual patch-clamp recordings was 0.356 +/- 0.024. The coupling reversibly decreased to 51 % of the control within 2 min of applying 100 microM ATP. Flash photolysis of 32 microM intracellular caged InsP3 and 1 mM caged Ca2+ reduced CR to 42 and 62 % of the control, respectively. 7. We propose that endolymphatic ATP via P2X and P2Y receptors can control intercellular communication amongst Hensen's cells by reducing gap junction conductance in a Ca2+- and InsP3-dependent manner." @default.
• W2122710090 created "2016-06-24" @default.
• W2122710090 creator A5011563842 @default.
• W2122710090 creator A5021438839 @default.
• W2122710090 creator A5036733660 @default.
• W2122710090 creator A5067381843 @default.
• W2122710090 date "2001-03-01" @default.
• W2122710090 modified "2023-10-18" @default.
• W2122710090 title "Purinergic control of intercellular communication between Hensen's cells of the guinea‐pig cochlea" @default.
• W2122710090 cites W1532324275 @default.
• W2122710090 cites W1604501714 @default.
• W2122710090 cites W1642980781 @default.
• W2122710090 cites W1815757713 @default.
• W2122710090 cites W1857434908 @default.
• W2122710090 cites W19383401 @default.
• W2122710090 cites W1968391665 @default.
• W2122710090 cites W1974248694 @default.
• W2122710090 cites W1977845454 @default.
• W2122710090 cites W1981163592 @default.
• W2122710090 cites W1984016122 @default.
• W2122710090 cites W1989632372 @default.
• W2122710090 cites W1991259792 @default.
• W2122710090 cites W2000147218 @default.
• W2122710090 cites W2014009598 @default.
• W2122710090 cites W2021527100 @default.
• W2122710090 cites W2030167054 @default.
• W2122710090 cites W2039372938 @default.
• W2122710090 cites W2060725506 @default.
• W2122710090 cites W2065840663 @default.
• W2122710090 cites W2069649254 @default.
• W2122710090 cites W2080097561 @default.
• W2122710090 cites W2083801316 @default.
• W2122710090 cites W2084821815 @default.
• W2122710090 cites W2097127990 @default.
• W2122710090 cites W2099041486 @default.
• W2122710090 cites W2103895907 @default.
• W2122710090 cites W2103915054 @default.
• W2122710090 cites W2114929889 @default.
• W2122710090 cites W2137150431 @default.
• W2122710090 cites W2164283705 @default.
• W2122710090 cites W2169040201 @default.
• W2122710090 cites W2253914059 @default.
• W2122710090 cites W2263253908 @default.
• W2122710090 cites W2286326724 @default.
• W2122710090 cites W2317669851 @default.
• W2122710090 cites W2398432501 @default.
• W2122710090 cites W2473165856 @default.
• W2122710090 doi "https://doi.org/10.1111/j.1469-7793.2001.0693h.x" @default.
• W2122710090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2278490" @default.
• W2122710090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251051" @default.
• W2122710090 hasPublicationYear "2001" @default.
• W2122710090 type Work @default.
• W2122710090 sameAs 2122710090 @default.
• W2122710090 citedByCount "49" @default.
• W2122710090 countsByYear W21227100902012 @default.
• W2122710090 countsByYear W21227100902013 @default.
• W2122710090 countsByYear W21227100902014 @default.
• W2122710090 countsByYear W21227100902015 @default.
• W2122710090 countsByYear W21227100902016 @default.
• W2122710090 countsByYear W21227100902018 @default.
• W2122710090 countsByYear W21227100902019 @default.
• W2122710090 countsByYear W21227100902022 @default.
• W2122710090 countsByYear W21227100902023 @default.
• W2122710090 crossrefType "journal-article" @default.
• W2122710090 hasAuthorship W2122710090A5011563842 @default.
• W2122710090 hasAuthorship W2122710090A5021438839 @default.
• W2122710090 hasAuthorship W2122710090A5036733660 @default.
• W2122710090 hasAuthorship W2122710090A5067381843 @default.
• W2122710090 hasBestOaLocation W21227100902 @default.
• W2122710090 hasConcept C115955781 @default.
• W2122710090 hasConcept C12554922 @default.
• W2122710090 hasConcept C147944092 @default.
• W2122710090 hasConcept C160225129 @default.
• W2122710090 hasConcept C170493617 @default.
• W2122710090 hasConcept C185592680 @default.
• W2122710090 hasConcept C2777427919 @default.
• W2122710090 hasConcept C2778071365 @default.
• W2122710090 hasConcept C2778597717 @default.
• W2122710090 hasConcept C2781387506 @default.
• W2122710090 hasConcept C28406088 @default.
• W2122710090 hasConcept C55493867 @default.
• W2122710090 hasConcept C57306754 @default.
• W2122710090 hasConcept C67018056 @default.
• W2122710090 hasConcept C79879829 @default.
• W2122710090 hasConcept C86803240 @default.
• W2122710090 hasConceptScore W2122710090C115955781 @default.
• W2122710090 hasConceptScore W2122710090C12554922 @default.
• W2122710090 hasConceptScore W2122710090C147944092 @default.
• W2122710090 hasConceptScore W2122710090C160225129 @default.
• W2122710090 hasConceptScore W2122710090C170493617 @default.
• W2122710090 hasConceptScore W2122710090C185592680 @default.
• W2122710090 hasConceptScore W2122710090C2777427919 @default.
• W2122710090 hasConceptScore W2122710090C2778071365 @default.
• W2122710090 hasConceptScore W2122710090C2778597717 @default.
• W2122710090 hasConceptScore W2122710090C2781387506 @default.
• W2122710090 hasConceptScore W2122710090C28406088 @default.
• W2122710090 hasConceptScore W2122710090C55493867 @default.
• W2122710090 hasConceptScore W2122710090C57306754 @default.

• next