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- W2122718922 abstract "Factors that influence the activity of prefrontal cortex (PFC) pyramidal neurons are likely to play an important role in working memory function. One such factor may be the release of Ca2+ from intracellular stores. Here we investigate the hypothesis that metabotropic glutamate receptors (mGluRs)-mediated waves of internally released Ca2+ can regulate the intrinsic excitability and firing patterns of PFC pyramidal neurons. Synaptic or focal pharmacological activation of mGluRs triggered Ca2+ waves in the dendrites and somata of layer V medial PFC pyramidal neurons. These Ca2+ waves often evoked a transient SK-mediated hyperpolarization followed by a prolonged depolarization that respectively decreased and increased neuronal excitability. Generation of the hyperpolarization depended on whether the Ca2+ wave invaded or came near to the soma. The depolarization also depended on the extent of Ca2+ wave propagation. We tested factors that influence the propagation of Ca2+ waves into the soma. Stimulating more synapses, increasing inositol trisphosphate concentration near the soma, and priming with physiological trains of action potentials all enhanced the amplitude and likelihood of evoking somatic Ca2+ waves. These results suggest that mGluR-mediated Ca2+ waves may regulate firing patterns of PFC pyramidal neurons engaged by working memory, particularly under conditions that favor the propagation of Ca2+ waves into the soma." @default.
- W2122718922 created "2016-06-24" @default.
- W2122718922 creator A5011639012 @default.
- W2122718922 creator A5037492837 @default.
- W2122718922 creator A5077969238 @default.
- W2122718922 date "2007-06-14" @default.
- W2122718922 modified "2023-10-06" @default.
- W2122718922 title "MGluR-Mediated Calcium Waves that Invade the Soma Regulate Firing in Layer V Medial Prefrontal Cortical Pyramidal Neurons" @default.
- W2122718922 cites W1499218111 @default.
- W2122718922 cites W1528754587 @default.
- W2122718922 cites W1540330207 @default.
- W2122718922 cites W1548031896 @default.
- W2122718922 cites W1567696719 @default.
- W2122718922 cites W1578372898 @default.
- W2122718922 cites W1585949905 @default.
- W2122718922 cites W1587009451 @default.
- W2122718922 cites W1604195904 @default.
- W2122718922 cites W1810474833 @default.
- W2122718922 cites W1812636860 @default.
- W2122718922 cites W1818623226 @default.
- W2122718922 cites W190501440 @default.
- W2122718922 cites W1906735024 @default.
- W2122718922 cites W1934970405 @default.
- W2122718922 cites W1939596644 @default.
- W2122718922 cites W1964991820 @default.
- W2122718922 cites W1974360309 @default.
- W2122718922 cites W1979273718 @default.
- W2122718922 cites W1983664266 @default.
- W2122718922 cites W1987463447 @default.
- W2122718922 cites W1990208186 @default.
- W2122718922 cites W1992206604 @default.
- W2122718922 cites W199752919 @default.
- W2122718922 cites W2015061703 @default.
- W2122718922 cites W2022388123 @default.
- W2122718922 cites W2023272552 @default.
- W2122718922 cites W2028268335 @default.
- W2122718922 cites W2029501430 @default.
- W2122718922 cites W2031534534 @default.
- W2122718922 cites W2033233884 @default.
- W2122718922 cites W2034507898 @default.
- W2122718922 cites W2035845442 @default.
- W2122718922 cites W2040353213 @default.
- W2122718922 cites W2043617261 @default.
- W2122718922 cites W2047338488 @default.
- W2122718922 cites W2050668851 @default.
- W2122718922 cites W2058396154 @default.
- W2122718922 cites W2062148835 @default.
- W2122718922 cites W2062977022 @default.
- W2122718922 cites W2070253406 @default.
- W2122718922 cites W2070683963 @default.
- W2122718922 cites W2073818625 @default.
- W2122718922 cites W2077788085 @default.
- W2122718922 cites W2077847569 @default.
- W2122718922 cites W2086166374 @default.
- W2122718922 cites W2088093088 @default.
- W2122718922 cites W2088442911 @default.
- W2122718922 cites W2088974782 @default.
- W2122718922 cites W2089232386 @default.
- W2122718922 cites W2096118295 @default.
- W2122718922 cites W2096519870 @default.
- W2122718922 cites W2101024344 @default.
- W2122718922 cites W2102721930 @default.
- W2122718922 cites W2106372134 @default.
- W2122718922 cites W2112614115 @default.
- W2122718922 cites W2119410682 @default.
- W2122718922 cites W2125619691 @default.
- W2122718922 cites W2136715772 @default.
- W2122718922 cites W2141492590 @default.
- W2122718922 cites W2142131601 @default.
- W2122718922 cites W2150991652 @default.
- W2122718922 cites W2157754546 @default.
- W2122718922 cites W2167809052 @default.
- W2122718922 cites W2170571477 @default.
- W2122718922 cites W2171108885 @default.
- W2122718922 cites W2229742325 @default.
- W2122718922 cites W2229872081 @default.
- W2122718922 cites W2259214560 @default.
- W2122718922 cites W2417122885 @default.
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- W2122718922 doi "https://doi.org/10.1093/cercor/bhm075" @default.
- W2122718922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3005283" @default.
- W2122718922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17573372" @default.
- W2122718922 hasPublicationYear "2007" @default.
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