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- W2122734847 abstract "Thymocytes mature in a series of stages by migrating through specific areas of the thymus and interacting with other cells to receive the necessary developmental signals; however, little is known about the molecular mechanisms governing this migration. We report that murine thymocytes with a knockout mutation in α-PAK (p21-activated kinase)-interacting exchange factor (PIX; Arhgef6), an activator of Rho GTPases, showed greatly increased motility and altered morphology in two-dimensional migration on ICAM-1. αPIX was also required for efficient positive selection, but not negative selection, of thymocytes. TCR signaling was normal in αPix(-) thymocytes, indicating that the effects of αPIX on positive selection are largely independent of TCR signaling. αPix(-) thymocytes also paused less during migration in the thymic cortex, interacted less with ICAM-1 coated beads, and could overcome TCR stop signals, consistent with defective scanning behavior. These results identify αPIX as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection." @default.
- W2122734847 created "2016-06-24" @default.
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- W2122734847 date "2014-04-01" @default.
- W2122734847 modified "2023-10-18" @default.
- W2122734847 title "αPIX RhoGEF Supports Positive Selection by Restraining Migration and Promoting Arrest of Thymocytes" @default.
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- W2122734847 doi "https://doi.org/10.4049/jimmunol.1302585" @default.
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