SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122764102> ?p ?o ?g. }

Showing items 1 to 100 of ±116 with 100 items per page.

W2122764102 endingPage "4724" @default.
W2122764102 startingPage "4716" @default.
W2122764102 abstract "We describe a novel, potent peptide substrate mimetic inhibitor of protein kinase B (PKB/Akt). The compound selectively kills prostate cancer cells, in which PKB is highly activated, but not normal cells, or cancer cells in which PKB is not activated. The inhibitor induces apoptosis and inhibits the phosphorylation of PKB substrates in prostate cancer cell lines and significantly increases the efficacy of chemotherapy agents to induce prostate cancer cell death, when given in combination. In vivo, the inhibitor exhibits a strong antitumor effect in two prostate cancer mouse models. Moreover, treated animals develop significantly less lung metastases compared to untreated ones, and the effect is accompanied by a significant decrease in blood PSA [prostate-specific antigen] levels in treated animals. This compound and its potential analogues may be developed into novel, potent, and safe anticancer agents, both as stand-alone treatment and in combination with other chemotherapy agents." @default.
W2122764102 created "2016-06-24" @default.
W2122764102 creator A5010899423 @default.
W2122764102 creator A5031344614 @default.
W2122764102 creator A5037737912 @default.
W2122764102 creator A5041017326 @default.
W2122764102 creator A5049671447 @default.
W2122764102 creator A5049962250 @default.
W2122764102 creator A5050074691 @default.
W2122764102 creator A5056071603 @default.
W2122764102 creator A5072669946 @default.
W2122764102 creator A5073111599 @default.
W2122764102 creator A5074178076 @default.
W2122764102 creator A5081346914 @default.
W2122764102 creator A5086417162 @default.
W2122764102 date "2007-03-31" @default.
W2122764102 modified "2023-09-23" @default.
W2122764102 title "A Novel Substrate Mimetic Inhibitor of PKB/Akt Inhibits Prostate Cancer Tumor Growth in Mice by Blocking the PKB Pathway" @default.
W2122764102 cites W1776913920 @default.
W2122764102 cites W1854708637 @default.
W2122764102 cites W1975483746 @default.
W2122764102 cites W1985803021 @default.
W2122764102 cites W1990841830 @default.
W2122764102 cites W2015278662 @default.
W2122764102 cites W2017362326 @default.
W2122764102 cites W2027811142 @default.
W2122764102 cites W2044938706 @default.
W2122764102 cites W2064504873 @default.
W2122764102 cites W2090551359 @default.
W2122764102 cites W2165863663 @default.
W2122764102 cites W2388163742 @default.
W2122764102 cites W2418425129 @default.
W2122764102 cites W4210631747 @default.
W2122764102 cites W4247904703 @default.
W2122764102 doi "https://doi.org/10.1021/bi061928s" @default.
W2122764102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17397140" @default.
W2122764102 hasPublicationYear "2007" @default.
W2122764102 type Work @default.
W2122764102 sameAs 2122764102 @default.
W2122764102 citedByCount "34" @default.
W2122764102 countsByYear W21227641022012 @default.
W2122764102 countsByYear W21227641022013 @default.
W2122764102 countsByYear W21227641022014 @default.
W2122764102 countsByYear W21227641022016 @default.
W2122764102 countsByYear W21227641022017 @default.
W2122764102 countsByYear W21227641022018 @default.
W2122764102 countsByYear W21227641022021 @default.
W2122764102 countsByYear W21227641022022 @default.
W2122764102 crossrefType "journal-article" @default.
W2122764102 hasAuthorship W2122764102A5010899423 @default.
W2122764102 hasAuthorship W2122764102A5031344614 @default.
W2122764102 hasAuthorship W2122764102A5037737912 @default.
W2122764102 hasAuthorship W2122764102A5041017326 @default.
W2122764102 hasAuthorship W2122764102A5049671447 @default.
W2122764102 hasAuthorship W2122764102A5049962250 @default.
W2122764102 hasAuthorship W2122764102A5050074691 @default.
W2122764102 hasAuthorship W2122764102A5056071603 @default.
W2122764102 hasAuthorship W2122764102A5072669946 @default.
W2122764102 hasAuthorship W2122764102A5073111599 @default.
W2122764102 hasAuthorship W2122764102A5074178076 @default.
W2122764102 hasAuthorship W2122764102A5081346914 @default.
W2122764102 hasAuthorship W2122764102A5086417162 @default.
W2122764102 hasConcept C121608353 @default.
W2122764102 hasConcept C126322002 @default.
W2122764102 hasConcept C150903083 @default.
W2122764102 hasConcept C185592680 @default.
W2122764102 hasConcept C190283241 @default.
W2122764102 hasConcept C207001950 @default.
W2122764102 hasConcept C2776235491 @default.
W2122764102 hasConcept C2780192828 @default.
W2122764102 hasConcept C502942594 @default.
W2122764102 hasConcept C55493867 @default.
W2122764102 hasConcept C71924100 @default.
W2122764102 hasConcept C75217442 @default.
W2122764102 hasConcept C86554907 @default.
W2122764102 hasConcept C86803240 @default.
W2122764102 hasConcept C96232424 @default.
W2122764102 hasConcept C98274493 @default.
W2122764102 hasConceptScore W2122764102C121608353 @default.
W2122764102 hasConceptScore W2122764102C126322002 @default.
W2122764102 hasConceptScore W2122764102C150903083 @default.
W2122764102 hasConceptScore W2122764102C185592680 @default.
W2122764102 hasConceptScore W2122764102C190283241 @default.
W2122764102 hasConceptScore W2122764102C207001950 @default.
W2122764102 hasConceptScore W2122764102C2776235491 @default.
W2122764102 hasConceptScore W2122764102C2780192828 @default.
W2122764102 hasConceptScore W2122764102C502942594 @default.
W2122764102 hasConceptScore W2122764102C55493867 @default.
W2122764102 hasConceptScore W2122764102C71924100 @default.
W2122764102 hasConceptScore W2122764102C75217442 @default.
W2122764102 hasConceptScore W2122764102C86554907 @default.
W2122764102 hasConceptScore W2122764102C86803240 @default.
W2122764102 hasConceptScore W2122764102C96232424 @default.
W2122764102 hasConceptScore W2122764102C98274493 @default.
W2122764102 hasIssue "16" @default.
W2122764102 hasLocation W21227641021 @default.
W2122764102 hasLocation W21227641022 @default.
W2122764102 hasOpenAccess W2122764102 @default.