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- W2122804918 abstract "Aim: Different nanoparticles have been investigated to deliver chemotherapeutic agents, but complex synthesis procedures and biocompatibility issues raise concerns in developing them for safe human usage. The aim of this work is to develop α,β-dehydrophenylalanine-containing, self-assembled, amphipathic dipeptide nanoparticles for tumor-targeted drug delivery and therapy. Material & methods: Solution-phase peptide synthesis was used to synthesize dipeptides. Nanoparticles were prepared by molecular self-assembly. A tumor distribution study was carried out using a radiolabeling method. Tumor regression studies were carried out in murine ascitic tumors in BALB/c mice and breast tumor xenografts in in nonobese diabetic/severe combined immuno¬deficiency mice. Results: Arg–α,β-dehydrophenylalanine formed self-assembled nanoparticles that could be easily derivatized with folic acid. Folic acid-derivatized nanoparticles showed enhanced cellular uptake and, when loaded with doxorubicin, showed enhanced tumor regression compared with underivatized nanoparticles or native drug, without any adverse side effects, both in vitro and in vivo. Original submitted 20 April 2012; Revised submitted 9 November 2012" @default.
- W2122804918 created "2016-06-24" @default.
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- W2122804918 date "2013-12-01" @default.
- W2122804918 modified "2023-09-30" @default.
- W2122804918 title "Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery" @default.
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- W2122804918 doi "https://doi.org/10.2217/nnm.12.201" @default.
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